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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Boot-Handford, R. P. | en |
| dc.contributor.author | Michaelidis, T. M. | en |
| dc.contributor.author | Hillarby, M. C. | en |
| dc.contributor.author | Zambelli, A. | en |
| dc.contributor.author | Denton, J. | en |
| dc.contributor.author | Hoyland, J. A. | en |
| dc.contributor.author | Freemont, A. J. | en |
| dc.contributor.author | Grant, M. E. | en |
| dc.contributor.author | Wallis, G. A. | en |
| dc.date.accessioned | 2015-11-24T16:31:52Z | - |
| dc.date.available | 2015-11-24T16:31:52Z | - |
| dc.identifier.issn | 0959-9673 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/7490 | - |
| dc.rights | Default Licence | - |
| dc.subject | bcl-2 | en |
| dc.subject | bcl-2 knockout mouse | en |
| dc.subject | growth plate | en |
| dc.subject | osteoblast | en |
| dc.subject | bone | en |
| dc.subject | collagen | en |
| dc.subject | hormone-related peptide | en |
| dc.subject | cell-cycle entry | en |
| dc.subject | parathyroid-hormone | en |
| dc.subject | skeletal development | en |
| dc.subject | targeted disruption | en |
| dc.subject | indian hedgehog | en |
| dc.subject | b-cells | en |
| dc.subject | cartilage | en |
| dc.subject | mice | en |
| dc.subject | expression | en |
| dc.title | The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | <Go to ISI>://000076792900008 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
| heal.publicationDate | 1998 | - |
| heal.abstract | Histological examination of long bones from 1-day-old bcl-2 knockout and age-matched control mice revealed no obvious differences in length of bone, growth plate architecture or stage of endochondral ossification. In 35-day-old bcl-2 knockout mice that are growth retarded or 'dwarfed', the proliferative zone of the growth plate appeared slightly thinner and the secondary centres of ossification less well developed than their age-matched wild-type controls. The most marked histological effects of bcl-2 ablation were on osteoblasts and bone. 35-day-old knockout mouse bones exhibited far greater numbers of osteoblasts than controls and the osteoblasts had a cuboidal phenotype in comparison with the normal flattened cell appearance. In addition, the collagen deposited by the osteoblasts in the bcl-2 knockout mouse bone was disorganized in comparison with control tissue and had a pseudo-woven appearance. The results suggest an important role for Bcl-2 in controlling osteoblast phenotype and bone deposition in vivo. | en |
| heal.journalName | International Journal of Experimental Pathology | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) | |
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