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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Karagiorga, G. | en |
| dc.contributor.author | Nakos, G. | en |
| dc.contributor.author | Galiatsou, E. | en |
| dc.contributor.author | Lekka, M. E. | en |
| dc.date.accessioned | 2015-11-24T16:53:07Z | - |
| dc.date.available | 2015-11-24T16:53:07Z | - |
| dc.identifier.issn | 0342-4642 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9973 | - |
| dc.rights | Default Licence | - |
| dc.subject | neutral lipids | en |
| dc.subject | phospholipase a(2) | en |
| dc.subject | acute lung injury | en |
| dc.subject | acute respiratory distress syndrome | en |
| dc.subject | platelet activating factor-acetylhydrolase | en |
| dc.subject | acute lung injury | en |
| dc.subject | secretory phospholipases a(2) | en |
| dc.subject | respiratory-distress-syndrome | en |
| dc.subject | acute chest syndrome | en |
| dc.subject | pulmonary surfactant | en |
| dc.subject | trauma patients | en |
| dc.subject | diagnosis | en |
| dc.subject | acetylhydrolase | en |
| dc.subject | quantitation | en |
| dc.subject | clearance | en |
| dc.title | Biochemical parameters of bronchoalveolar lavage fluid in fat embolism | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | DOI 10.1007/s00134-005-2868-x | - |
| heal.identifier.secondary | <Go to ISI>://000234410900020 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/yhkv683k1k220577/fulltext.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2006 | - |
| heal.abstract | Objective: To identify diagnostic markers distinguishing between acute lung injury/acute respiratory distress syndrome (ALI/ARDS) due to fat embolism syndrome (FES) and that due to other causes, and to investigate whether phospholipase A(2) and platelet-activating factor (PAF) play a role in the pathogenesis of ALI due to FES. Design and settings: A prospective study in a 14-bed ICU. Patients: We studied 13 patients with FES, 11 with ALI/ARDS from other causes (6 without trauma, ALI/ARDS group 1; 7 with trauma, ALI/ARDS group 2) and 5 without cardiopulmonary disease. Measuremens and results: We compared broncholveolar lavage (BAL) fluid alterations in the respective groups. Total BAL protein in FES group was significantly higher compared to in ALI/ARDS group 1 and controls but ALI/ARDS group 2. Higher total phospholipids were found than in other groups. The alterations in individual phospholipid classes were similar to those in ALI/ARDS patients. However, total cholesterol, lipid esters, and monoglycerides were significantly higher in FES than in other groups. The level of PAF in FES was significantly higher and there was an inverse correlation between PAF and PAF-acetylhydrolase. Phospholipase A(2) activity was significantly higher in both FES and ALI/ARDS groups than in control. Conclusions: The levels of neutral lipids and especially cholesterol and cholesterol esters in BAL can be used to distinguish patients with FES from ALI/ARDS due to other predisposing factors. Phospholipase A(2) may be involved in the development, and PAF-acetylhydrolase in the downregulation of inflammation in FES. | en |
| heal.publisher | Springer Verlag (Germany) | en |
| heal.journalName | Intensive Care Med | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Karagiorga-2006-Biochemical paramete.pdf | 204.68 kB | Adobe PDF | View/Open Request a copy |
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