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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/9854
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dc.contributor.authorNakos, G.en
dc.contributor.authorTziakou, E.en
dc.contributor.authorManeta-Peyret, L.en
dc.contributor.authorNassis, C.en
dc.contributor.authorLekka, M. E.en
dc.date.accessioned2015-11-24T16:52:15Z-
dc.date.available2015-11-24T16:52:15Z-
dc.identifier.issn0342-4642-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9854-
dc.rightsDefault Licence-
dc.subjectguillain-barre syndromeen
dc.subjectdemyelinationen
dc.subjectantiphospholipid antibodiesen
dc.subjectautoantibodiesen
dc.subjectgamma-globulinen
dc.subjectcampylobacter-jejuni infectionen
dc.subjectsystemic-lupus-erythematosusen
dc.subjectantiganglioside antibodiesen
dc.subjectautoantibodiesen
dc.subjectphospholipidsen
dc.subjectmyelinen
dc.subjectlipopolysaccharidesen
dc.subjectneuropathyen
dc.subjectdiseasesen
dc.subjectprofileen
dc.titleAnti-phospholipid antibodies in serum from patients with Guillain-Barre syndromeen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1007/s00134-005-2736-8-
heal.identifier.secondary<Go to ISI>://000232560300014-
heal.identifier.secondaryhttp://www.springerlink.com/content/v0273r14n4830943/fulltext.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate2005-
heal.abstractObjective: The Guillain-Barre syndrome (GBS) is an acute inflammatory polyneuropathy related to autoimmunity. However, no conclusive etiological concept has yet been found. We examined the variation in autoantibodies to lipids in serum of GBS patients in response to the course of the disease but investigated titer modifications during treatment with gamma-globulin. Design and setting: Prospective clinical study in a 14-bed general ICU. Patients: Nine patients with GBS and nine controls were included in the study. Measurements and results: Four blood samples were obtained before and after treatment. Serum samples, diluted 1:60, were tested by enzyme-linked immunosorbent assay for IgM, IgA, and IgG antibodies to phosphatidylcholine, phosphatidylinositol, cardiolipin, phosphatidic acid, phosphatidylserine, phosphatidylglycerol, phosphatidylethanolamine, sphingomyelin, and gangliosides. Anti-phospholipid antibodies of the IgM, IgA, and IgG families were detected in all GBS patients but in none of the controls. Phosphatidylinositol, cardiolipin, phosphatidylcholine, and phosphatidic acid were the main antigens. All patients developed anti-phosphatidylinositol antibodies of the IgM family and anti-cardiolipin antibodies of the IgA and IgG families. A decrease in the level of anti-phospholipid autoantibodies was observed after 1 day of treatment with gamma-globulin. Two days after ending gamma-globulin administration the IgG antibodies increased again. Conclusions: Our findings suggest that in GBS there is an extensive immune reaction, which is altered after gamma-globulin treatment. Anti-cardiolipin and anti-phosphatidylinositol antibodies could be useful markers for the response to treatment.en
heal.publisherSpringer Verlag (Germany)en
heal.journalNameIntensive Care Meden
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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