1. Repository of OAI
  2. ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"
  3. Σχολή Θετικών Επιστημών
  4. Τμήμα Χημείας
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ
Ελληνικά   English  
Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/9818
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLiberopoulos, E. N.en
dc.contributor.authorElisaf, M. S.en
dc.contributor.authorTselepis, A. D.en
dc.contributor.authorArchimandritis, A.en
dc.contributor.authorKiskinis, D.en
dc.contributor.authorCokkinos, D.en
dc.contributor.authorMikhailidis, D. P.en
dc.date.accessioned2015-11-24T16:52:01Z-
dc.date.available2015-11-24T16:52:01Z-
dc.identifier.issn0953-7104-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9818-
dc.rightsDefault Licence-
dc.subjectaspirinen
dc.subjectclopidogrelen
dc.subjectcoronary heart diseaseen
dc.subjectgastrointestinal bleedingen
dc.subjectstrokeen
dc.subjectpeptic ulceren
dc.subjectproton pump inhibitoren
dc.subjectacute coronary syndromesen
dc.subjectst-segment elevationen
dc.subjectlow-dose aspirinen
dc.subjectnonsteroidal antiinflammatory drugsen
dc.subjecthelicobacter-pylori infectionen
dc.subjectrandomized controlled-trialen
dc.subjectpump inhibitor therapyen
dc.subjectpeptic-ulcer diseaseen
dc.subjecthigh-risk patientsen
dc.subjectmyocardial-infarctionen
dc.titleUpper gastrointestinal haemorrhage complicating antiplatelet treatment with aspirin and/or clopidogrel: Where we are now?en
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDoi 10.1080/09537100500237004-
heal.identifier.secondary<Go to ISI>://000233578500001-
heal.identifier.secondaryhttp://informahealthcare.com/doi/abs/10.1080/09537100500237004-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate2006-
heal.abstractA large number of patients require antiplatelet therapy (mainly aspirin and/or clopidogrel). Recent studies suggest that the combination of these agents is useful in patients with acute coronary syndrome and after percutaneous coronary intervention with stent placement. On the other hand, bleeding complications, most of which arise from the upper gastrointestinal (UGI) tract, can limit the use of antiplatelet drugs. Clopidogrel appears to be associated with fewer UGI side effects and bleeding compared with aspirin. However, a history of previous UGI bleeding is a major risk factor for clopidogrel-associated bleeding. The use of proton-pump inhibitors (PPIs) decreases the rate of UGI bleeding in patients receiving aspirin or clopidogrel. Furthermore, a recent study suggested that the administration of low-dose aspirin plus high-dose esomeprazole (a potent PPI) was associated with fewer episodes of UGI bleeding than clopidogrel alone in patients with a history of recent UGI haemorrhage. However, this study had several limitations and its results should be cautiously extrapolated into clinical practice. The combination of aspirin plus clopidogrel increases the risk of UGI bleeding. Unfortunately, there are no data on the effect of PPI prophylaxis in this setting. Available evidence suggests that where aspirin and/or clopidogrel are to be started or continued in patients with a recent history of UGI ulceration or bleeding (after ulcer healing and eradication of H. pylori infection), treatment with a PPI is a useful precaution. The patients should also be carefully monitored for recurrence of UGI bleeding.en
heal.journalNamePlateletsen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ

Show simple item record
Files in This Item:
There are no files associated with this item.
Show simple item record  


This item is licensed under a Creative Commons License Creative Commons