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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/9795
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dc.contributor.authorTsikaris, V.en
dc.contributor.authorPetit, M. C.en
dc.contributor.authorOrlewski, P.en
dc.contributor.authorSakarellos-Daitsiotis, M.en
dc.contributor.authorSakarellos, C.en
dc.contributor.authorTzinia, A.en
dc.contributor.authorKonidou, G.en
dc.contributor.authorSoteriadou, K. P.en
dc.contributor.authorMarraud, M.en
dc.contributor.authorCung, M. T.en
dc.date.accessioned2015-11-24T16:51:51Z-
dc.date.available2015-11-24T16:51:51Z-
dc.identifier.issn0929-5666-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9795-
dc.rightsDefault Licence-
dc.subjectantigen-antibody interactionen
dc.subjectantigenic peptideen
dc.subjectleishmania gp63en
dc.subjectmolecular dynamicsen
dc.subjectsryd motifen
dc.subject2d nmren
dc.subjectmajor surface glycoproteinen
dc.subjectprotease gp63en
dc.subjectcell-adhesionen
dc.subjectpromastigotesen
dc.subjectspectroscopyen
dc.subjectfibronectinen
dc.subjectregionen
dc.subjectmimicsen
dc.subjectsiteen
dc.titleTR-NOE and MD studies of Leishmania gp63 SRYD-containing sequences bound to anti-SRYD monoclonal antibodyen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondary<Go to ISI>://000071627900023-
heal.identifier.secondaryhttp://www.springerlink.com/content/862820n641018206/fulltext.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate1997-
heal.abstractThe I(250)ASRYDQL(257) synthetic octapeptide of the Leishmania major surface glycoprotein gp63, which efficiently inhibits parasite attachment to the macrophage receptors and mimics antigenically and functionally the RGDS sequence of fibronectin, was studied by 2D TR-NOESY in the presence of an anti-SRYD monoclonal antibody (mAbSRYD) that recognizes both SRYD-containing peptides and the cognate protein on intact parasites. Molecular modeling was performed using distance constraints obtained from TR-NOEs. The bound structure was compared with that of the free peptide in DMSO solution and with the crystal structure of the RYD fragment of the OPG2 Feb, an antireceptor antibody that mimics an RGD cell adhesion site.en
heal.publisherKluwer Academic Publishersen
heal.journalNameLetters in Peptide Scienceen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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