Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/9654
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dc.contributor.authorSkalkos, D.en
dc.contributor.authorStavropoulos, N. E.en
dc.contributor.authorTsimaris, I.en
dc.contributor.authorGioti, E.en
dc.contributor.authorStalikas, C. D.en
dc.contributor.authorNseyo, U. O.en
dc.contributor.authorIoachim, E.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T16:50:52Z-
dc.date.available2015-11-24T16:50:52Z-
dc.identifier.issn0032-0943-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9654-
dc.rightsDefault Licence-
dc.subjecthypericum perforatum l.en
dc.subjectst. john's worten
dc.subjecthypericinen
dc.subjectpseudohypericinen
dc.subjecthyperforinen
dc.subjectchlorophyllsen
dc.subjectbladder tumoren
dc.subjectst-johns-worten
dc.subjectforced swimming testen
dc.subjectantidepressant activityen
dc.subjectin-vitroen
dc.subjectcanceren
dc.subjecthyperforinen
dc.subjectapoptosisen
dc.subjectconstituenten
dc.subjectflavonoidsen
dc.subjectinhibitionen
dc.titleThe lipophilic extract of Hypericum perforatum exerts significant cytotoxic activity against T24 and NBT-II urinary bladder tumor cellsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1055/s-2005-873127-
heal.identifier.secondary<Go to ISI>://000233940800008-
heal.identifier.secondaryhttps://www.thieme-connect.de/DOI/DOI?10.1055/s-2005-873127-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate2005-
heal.abstractHypericum perforatum L (St. John's wort) is a medicinal plant used for many pathologies, especially for the treatment of mild to moderate depression. In the present study we have investigated the cytotoxic activity of the locally collected (Epirus region) Hypericum perforatum L. against cultured T24 and NBT-II bladder cancer cell lines. The lipophilic extract of the herb, prepared using petroleum ether, induced apoptosis displaying LC50 values at concentrations as low as 4 and 5 mu g/mL. A fraction of this extract displayed 60% cell growth inhibition at a concentration of 0.95 mu g/mL. Evaluating the importance of various biologically active components of the extract, it was found that hypericins (hypericin, pseudohypericin, etc.) were identified only in the methanolic (lipophobic) extract of the herb, and not in the active lipophilic extract. In addition, hyperforin concentrations in the lipophilic extract and its most active fraction, were 0.94 mu g/mL, and 0.17 mu g/mL, respectively, while the active cytotoxic concentration of pure hyperforin appeared in the range of 1.8 mu g/mL - 5.0 mu g/mL. Therefore, pure hyperforin does not seem to contribute significantly to the cytotoxicity activity. Chlorophylls were identified in low, not significantly different, concentrations in all extracts and fractions and were not correlated to the biological activity. Owing to the combination of significant cytotoxic activity, natural abundance and low toxicity, the lipophilic extract of Hypericum perforatum holds the promise of being an interesting, new, anti proliferative agent against bladder cancer that deserves further investigation.en
heal.publisherGeorg Thieme Verlagen
heal.journalNamePlanta Medicaen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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