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DC Field | Value | Language |
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dc.contributor.author | Shpakovsky, D. B. | en |
dc.contributor.author | Banti, C. N. | en |
dc.contributor.author | Beaulieu-Houle, G. | en |
dc.contributor.author | Kourkoumelis, N. | en |
dc.contributor.author | Manoli, M. | en |
dc.contributor.author | Manos, M. J. | en |
dc.contributor.author | Tasiopoulos, A. J. | en |
dc.contributor.author | Hadjikakou, S. K. | en |
dc.contributor.author | Milaeva, E. R. | en |
dc.contributor.author | Charalabopoulos, K. | en |
dc.contributor.author | Bakas, T. | en |
dc.contributor.author | Butler, I. S. | en |
dc.contributor.author | Hadjiliadis, N. | en |
dc.date.accessioned | 2015-11-24T16:49:47Z | - |
dc.date.available | 2015-11-24T16:49:47Z | - |
dc.identifier.issn | 1477-9226 | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9528 | - |
dc.rights | Default Licence | - |
dc.subject | organotin(iv) complexes | en |
dc.subject | spectral characterization | en |
dc.subject | acid | en |
dc.subject | derivatives | en |
dc.subject | ligands | en |
dc.subject | 5-chloro-2-mercaptobenzothiazole | en |
dc.subject | 2-mercaptobenzothiazole | en |
dc.subject | metalloporphyrins | en |
dc.subject | peroxidation | en |
dc.subject | thioamides | en |
dc.title | Synthesis, structural characterization and in vitro inhibitory studies against human breast cancer of the bis-(2,6-di-tert-butylphenol)tin(IV) dichloride and its complexes | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.primary | Doi 10.1039/C2dt31527k | - |
heal.identifier.secondary | <Go to ISI>://000311520000013 | - |
heal.identifier.secondary | http://pubs.rsc.org/en/Content/ArticleLanding/2012/DT/c2dt31527k | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
heal.publicationDate | 2012 | - |
heal.abstract | Four new organotin(IV) complexes of bis-(2,6-di-tert-butylphenol)tin(IV) dichloride [(tert-Bu-)(2)(HO-Ph)](2)SnCl2 (1) with the heterocyclic thioamides 2-mercapto-pyrimidine (PMTH), 2-mercapto-4-methyl-pyrimidine (MPMTH), 2-mercapto-pyridine (PYTH) and 2-mercapto-benzothiazole (MBZTH), of formulae {[(tert-Bu-)(2)(HO-Ph)](2)Sn(PMT)(2)}(2), {[(tert-Bu-)(2)(HO-Ph)](2)Sn(MPMT)(2)} (3), {[(tert-Bu-)(2)(HO-Ph)](2)SnCl(PYT)} (4) and {[(tert-Bu-)(2)(HO-Ph)](2)SnCl(MBZT)} (5), have been ;synthesized and characterized by elemental analysis, H-1-, C-13-, Sn-119-NMR, EPR, FT-IR, Raman and Mossbauer spectroscopic techniques. The crystal and molecular structures of compounds 1-5 have been determined by X-ray diffraction. The geometries around the metal center adopted in complexes 1-5 varied between tetrahedral in 1, trigonal bipyramidal in 3, 4, 5 and distorted octahedral in 2. Two carbon atoms from aryl groups and two chlorine atoms form a distorted tetrahedron in the case of 1. Two carbon, two sulfur and two nitrogen atoms from thione ligands form a distorted octahedral geometry around tin (IV) with trans-C-2, cis-N-2, cis-S-2-configurations in 2. However, in the case of 4 and 5 complexes two carbon, one sulfur, one nitrogen and one chloride atom form a distorted trigonal bipyramidal arrangement. Finally, in the case of 3 the trigonal bipyramidal geometry is achieved by two carbon, two sulfur and one nitrogen atom in a unique coordination mode of thioamides toward the tin(IV) cation. Compounds 1-5 were tested for their in vitro cytotoxicity against the human breast adenocarcinoma (MCF-7) cell line. Compound 3 exhibits strong cytotoxic activity against MCF-7 cells (IC50 = 0.58 +/- 0.1 mu M). | en |
heal.publisher | Royal Society of Chemistry | en |
heal.journalName | Dalton Transactions | en |
heal.journalType | peer reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ |
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Manos-2012-Synthesis, structural characterization.pdf | 3.32 MB | Adobe PDF | View/Open Request a copy |
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