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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Poyraz, M. | en |
| dc.contributor.author | Banti, C. N. | en |
| dc.contributor.author | Kourkoumelis, N. | en |
| dc.contributor.author | Dokorou, V. | en |
| dc.contributor.author | Manos, M. J. | en |
| dc.contributor.author | Simcic, M. | en |
| dc.contributor.author | Golic-Grdadolnik, S. | en |
| dc.contributor.author | Mavromoustakos, T. | en |
| dc.contributor.author | Giannoulis, A. D. | en |
| dc.contributor.author | Verginadis, I. I. | en |
| dc.contributor.author | Charalabopoulos, K. | en |
| dc.contributor.author | Hadjikakou, S. K. | en |
| dc.date.accessioned | 2015-11-24T16:49:40Z | - |
| dc.date.available | 2015-11-24T16:49:40Z | - |
| dc.identifier.issn | 0020-1693 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9517 | - |
| dc.rights | Default Licence | - |
| dc.subject | bioinorganic chemistry | en |
| dc.subject | silver(i) complexes | en |
| dc.subject | aspirin | en |
| dc.subject | crystal structures | en |
| dc.subject | cytotoxic activity | en |
| dc.subject | std h-1 nmr | en |
| dc.subject | crystal-structure | en |
| dc.subject | silver(i) complexes | en |
| dc.subject | in-vitro | en |
| dc.subject | anticonvulsant activities | en |
| dc.subject | derivatives | en |
| dc.subject | organotin(iv) | en |
| dc.subject | lipoxygenase | en |
| dc.subject | thioamides | en |
| dc.subject | dinuclear | en |
| dc.subject | gold(i) | en |
| dc.title | Synthesis, structural characterization and biological studies of novel mixed ligand Ag(I) complexes with triphenylphosphine and aspirin or salicylic acid | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | DOI 10.1016/j.ica.2011.04.032 | - |
| heal.identifier.secondary | <Go to ISI>://000293783900016 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0020169311003896/1-s2.0-S0020169311003896-main.pdf?_tid=548a64a2-3636-11e3-a0e8-00000aacb361&acdnat=1381909452_a621d28f02a1aafbbf2f4030f480086b | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2011 | - |
| heal.abstract | Two new mixed ligand silver(I) complexes of formulae {[Ag(tpp)(3)(asp)](dmf)} (1) (aspH = o-acetylsalicylic acid and tpp = triphenylphosphine) and [Ag(tpp)(2)(o-Hbza)] (2) (o-HbzaH = o-hydroxy-benzoic acid) were synthesized and characterized by elemental analyses, spectroscopic techniques and X-ray crystallography at ambient conditions. Three phosphorus and one carboxylic oxygen atoms from a de-protonated aspirin ligand in complex 1 and two phosphorus and two carboxylic oxygen atoms from a chelating o-Hbza anion in complex 2 form a tetrahedral geometry around Ag(I) ions in both complexes. Complexes 1 and 2 and the silver(I) nitrate, tpp, aspNa and o-HbzaH were tested for their in vitro cytotoxic activity against leiomyosarcoma cells (LMS), human breast adenocarcinoma cells (MCF-7) and normal human fetal lung fibroblasts (MRC-5) cells with Thiazolyl Blue Tetrazolium Bromide (MTT) assay. For both cell lines 1 and 2 were found to be more active than cisplatin. Additionally, 1 and 2 exhibit lower activity on cell growth proliferation of MRC-5 cells. The type of LMS cell death caused by 1 and 2 were evaluated in vitro by use of flow cytometry assay. The results show that at concentrations of 1.5 and 1.9 mu M of complex 1, 44.1% and 69.4%, respectively of LMS cells undergo programmed cell death (apoptosis). When LMS cells were treated with 1.6 and 2.3 mu M of 2, LMS cells death was by 29.6% and 81.3%, respectively apoptotic. Finally, the influence of the complexes 1 and 2, upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically and theoretically studied. The binding of 1 and 2 towards LOX was also investigated by Saturation Transfer Difference (STD) H-1 NMR experiments. (C) 2011 Elsevier B.V. All rights reserved. | en |
| heal.publisher | Elsevier | en |
| heal.journalName | Inorganica Chimica Acta | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Poyraz-2011-Synthesis, structura.pdf | 833.2 kB | Adobe PDF | View/Open Request a copy |
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