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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/9498
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dc.contributor.authorKovala-Demertzi, D.en
dc.contributor.authorAlexandratos, A.en
dc.contributor.authorPapageorgiou, A.en
dc.contributor.authorYadav, P. N.en
dc.contributor.authorDalezis, P.en
dc.contributor.authorDemertzis, M. A.en
dc.date.accessioned2015-11-24T16:49:32Z-
dc.date.available2015-11-24T16:49:32Z-
dc.identifier.issn0277-5387-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9498-
dc.rightsDefault Licence-
dc.subjectpalladium(ii, zinc(ii)) complexesen
dc.subjectthiosemicarbazonato complexesen
dc.subjectcrystal structureen
dc.subjectspectroscopic studiesen
dc.subjectanti-tumor activityen
dc.subjectrapid colorimetric assayen
dc.subjectplatinum(ii) complexesen
dc.subjectspectral propertiesen
dc.subjectpyridine-2-carbaldehyde thiosemicarbazoneen
dc.subject4n-ethyl thiosemicarbazoneen
dc.subjectantiproliferative activityen
dc.subjectribonucleotide reductaseen
dc.subjectbiological-activityen
dc.subjectcytotoxic activityen
dc.subjectcell-linesen
dc.titleSynthesis, characterization, crystal structures, in vitro and in vivo antitumor activity of palladium(II) and zinc(II) complexes with 2-formyl and 2-acetyl pyridine N(4)-1-(2-pyridyl)-piperazinyl thiosemicarbazoneen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1016/j.poly.2008.04.009-
heal.identifier.secondary<Go to ISI>://000259712800001-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0277538708002003/1-s2.0-S0277538708002003-main.pdf?_tid=b969958c254690ffdf03f24d51f96f20&acdnat=1333028645_531cdd149caf8b6d809a1733899a0fb6-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate2008-
heal.abstractThe present paper includes synthesis and spectral characterization of the novel prepared palladium(B) and zinc(II) complexes with 2-formyl pyridine N(4)-1-(2-pyridyl)-piperazinyl thiosemicarbazone, HFo4Npypipe, 1 and the 2-acetyl pyridine N(4)-1-(2-pyridyl)-piperazinyl thiosemicarbazone, HAc4Npy-pipe, 2. The Pd(II) complexes [PdCl(Fo4Npypipe)], 3, [PdCl(Ac4Npypipe)], 4 and the Zn(II) complexes [ZnCl(2)(Fo4Npypipe)], 5 and [ZnCl(2)(Ac4Npypipe)], 6 have been characterized by elemental analyses and spectroscopic studies. The crystal structure of the complexes [PdCl(Fo4Npippy)], 3 and [PdCl(Ac4N-pippy)], 4, have been solved by single-crystal X-ray diffraction. The electronic, IR, UV/Vis, and NMR spectroscopic data of the complexes are reported. The results of the cytotoxic activity of 1-6 have been evaluated in vitro against the cells of three human cancer cell lines: MCF-7, T24, A-549 and a mouse L-929 (a fibroblast-like cell line cloned from strain Q. For selected compounds 2 and 6 the acute toxicity and antitumor activity were evaluated on leukemia P388-bearing mice. The Zn(II) compounds 5 and 6 are considered as agents with potential antitumor activity, and can therefore be candidates for further stages of screening in vitro and/or in vivo. (C) 2008 Elsevier Ltd. All rights reserved.en
heal.journalNamePolyhedronen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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