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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kovala-Demertzi, D. | en |
| dc.contributor.author | Galani, A. | en |
| dc.contributor.author | Kourkoumelis, N. | en |
| dc.contributor.author | Miller, J. R. | en |
| dc.contributor.author | Demertzis, M. A. | en |
| dc.date.accessioned | 2015-11-24T16:49:31Z | - |
| dc.date.available | 2015-11-24T16:49:31Z | - |
| dc.identifier.issn | 0277-5387 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9497 | - |
| dc.rights | Default Licence | - |
| dc.subject | platinum(ii) complexes | en |
| dc.subject | thiosemicarbazonato complexes | en |
| dc.subject | crystal structure | en |
| dc.subject | spectroscopic studies | en |
| dc.subject | antineoplastic activity | en |
| dc.subject | rapid colorimetric assay | en |
| dc.subject | palladium(ii) complexes | en |
| dc.subject | spectral properties | en |
| dc.subject | antitumor-activity | en |
| dc.subject | 2-acetyl pyridine | en |
| dc.subject | pyridine-2-carbaldehyde thiosemicarbazone | en |
| dc.subject | ribonucleotide reductase | en |
| dc.subject | biological-activity | en |
| dc.subject | cytotoxic activity | en |
| dc.subject | metal-complexes | en |
| dc.title | Synthesis, characterization, crystal structure and antiproliferative activity of platinum(II) complexes with 2-acetylpyridine-4-cyclohexyl-thiosemicarbazone | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | DOI 10.1016/j.poly.2007.01.039 | - |
| heal.identifier.secondary | <Go to ISI>://000248633900063 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0277538707000587/1-s2.0-S0277538707000587-main.pdf?_tid=bbaccef99b6801e7a389fe895379d177&acdnat=1333028748_720bcba57c5dfc50ad087510b81f40bd | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2007 | - |
| heal.abstract | New platinum complexes have been synthesized by the reaction of Na2PtCl4 with 2-acetylpyridine-4-cyclohexyl-thiosemicarbazone, HAc4CyclHexyl (1). The new complexes [Pt(Ac4Cyc1Hexyl)Cl] (2) and [Pt(Ac4CyclHexyl)(2)] (3) have been characterized by elemental analyses and spectroscopic studies. The crystal structure of the complex [Pt(Ac4CyclHexy1)Cl] - DMF has been solved by single-crystal X-ray diffraction. The anion of Ac4CyclHexyl coordinates in a planar conformation to the central platinum(II) through the pyridyl N, azomethine N and thiolato S atoms. The crystal packing is determined by double intermolecular hydrogen interactions, pi-pi, Pt-C and Pt-pi contacts. The cytotoxic activities of 1-3 have been evaluated for antiproliferative activity in vitro against the cells of three human cancer cell lines: MCF-7 (human breast cancer cell line), T24 (bladder cancer cell line), A-549 (non-small cell lung carcinoma) and a mouse L-929 (a fibroblast-like cell line cloned from strain L). The compounds 1-3 display IC50 values in a mu M range better than that of the antitumor drug cisplatin and are considered as agents with potential antitumor activity candidates for further stages of screening in vitro and/or in vivo. (C) 2007 Elsevier Ltd. All rights reserved. | en |
| heal.journalName | Polyhedron | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kovala-Demertzi-2007-Synthesis, character.pdf | 593.83 kB | Adobe PDF | View/Open Request a copy |
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