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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Zachariadis, P. C. | en |
| dc.contributor.author | Hadjikakou, S. K. | en |
| dc.contributor.author | Hadjiliadis, N. | en |
| dc.contributor.author | Skoulika, S. | en |
| dc.contributor.author | Michaelides, A. | en |
| dc.contributor.author | Balzarini, J. | en |
| dc.contributor.author | De Clercq, E. | en |
| dc.date.accessioned | 2015-11-24T16:49:29Z | - |
| dc.date.available | 2015-11-24T16:49:29Z | - |
| dc.identifier.issn | 1434-1948 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9492 | - |
| dc.rights | Default Licence | - |
| dc.subject | bioinorganic chemistry | en |
| dc.subject | silver | en |
| dc.subject | x-ray diffraction | en |
| dc.subject | cytostatic activity | en |
| dc.subject | antiviral activity | en |
| dc.subject | hindered thiolate ligands | en |
| dc.subject | crystal-structure | en |
| dc.subject | molecular-structure | en |
| dc.subject | copper-complexes | en |
| dc.subject | cluster | en |
| dc.subject | pyridine-2(1h)-thione | en |
| dc.subject | dihydrogen | en |
| dc.subject | gold(i) | en |
| dc.subject | donors | en |
| dc.subject | acid | en |
| dc.title | Synthesis, characterization and in vitro study of the cytostatic and antiviral activity of new polymeric silver(I) complexes with ribbon structures derived from the conjugated heterocyclic thioamide 2-mercapto-3,4,5,6-tetrahydropyrimidine | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | DOI 10.1002/ejic.200300672 | - |
| heal.identifier.secondary | <Go to ISI>://000220797100008 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/ejic.200300672/asset/1420_ftp.pdf?v=1&t=h0dvqj5g&s=498738d4c88cbf1f0bf69ed87f8f692068821564 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2004 | - |
| heal.abstract | Silver(I) bromide reacts with 2-mercapto-3,4,5,6-tetrahydropyrimidine (StpmH(2), C4H8N2S) in DMSO with an excess of triethylamine to give a water-insoluble complex of formula [Ag-6(mu(2)-Br)(6)(mu(2)-StpmH(2))(4)(mu(3)-StpmH(2))(2)](n) (1), while the reaction of silver(I) nitrate with StpmH(2) under the same conditions gives a water-insoluble complex of formula [{Ag-4(mu(2)-StpmH(2))(6)}(NO3)(4)](n) (2). The products were characterized by elemental analyses, and FT-IR far-IR, UV/Vis, H-1 and C-13 NMR spectroscopy. Crystal structures of complexes 1 and 2 were determined by X-ray diffraction. Complex 1, C24H48Ag6N12S6, crystallizes in the triclinic system space group P (1) over bar, a = 8.041(1) Angstrom, b = 12.838(4) Angstrom, c = 13.281(2) Angstrom, alpha = 68.40(1)degrees, = 72.97(1)degrees, gamma = 87.80(2), Z = 2, forming a one-dimensional infinite ribbon structure by strong interatomic interactions of two mu(2)-Br bonds with Ag(1). Complex 2, C24H48Ag4N16O12S6, crystallizes in the orthorhombic system, space group Cmc2(1), and a = 32.148(3) Angstrom, b = 9.461(2) Angstrom, c = 7.234(1) Angstrom, alpha = beta = gamma = 90degrees, Z = 8, forming infinite Ag-S-Ag chains which are bridged to each other by a sulfur atom of mu(2)-StpmH(2) ligands. Complexes 1 and 2 were studied for their cytostatic activity against murine leukemia (L1210) and human T-lymphocyte (Molt4/C8 and CEM) cells and for their antiviral activity against a wide variety of viruses. They are markedly cytostatic at 50% inhibitory concentration (IC50) values ranging from 3 to 17 mug/mL. None of the compounds showed appreciable antiviral activity at subtoxic concentrations. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004. | en |
| heal.publisher | Wiley-VCH Verlag | en |
| heal.journalName | European Journal of Inorganic Chemistry | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Zachariadis-2004-Synthesis, character.pdf | 229.06 kB | Adobe PDF | View/Open Request a copy |
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