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DC Field | Value | Language |
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dc.contributor.author | Antoniadis, C. D. | en |
dc.contributor.author | Hadjikakou, S. K. | en |
dc.contributor.author | Hadjiliadis, N. | en |
dc.contributor.author | Papakyriakou, A. | en |
dc.contributor.author | Baril, M. | en |
dc.contributor.author | Butler, I. S. | en |
dc.date.accessioned | 2015-11-24T16:49:09Z | - |
dc.date.available | 2015-11-24T16:49:09Z | - |
dc.identifier.issn | 0947-6539 | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9437 | - |
dc.rights | Default Licence | - |
dc.subject | bioinorganic chemistry | en |
dc.subject | charge-transfer complexes | en |
dc.subject | heterocyclic selenoamides | en |
dc.subject | iodine adducts | en |
dc.subject | selenium | en |
dc.subject | i iodothyronine deiodinase | en |
dc.subject | thyroid-hormone synthesis | en |
dc.subject | ray crystal-structures | en |
dc.subject | x-ray | en |
dc.subject | transfer complexes | en |
dc.subject | spectroscopic characterization | en |
dc.subject | molecular adducts | en |
dc.subject | selenium analog | en |
dc.subject | ft-raman | en |
dc.subject | iodine | en |
dc.title | Synthesis and structures of Se analogues of the antithyroid drug 6-n-propyl-2-thiouracil and its alkyl derivatives: Formation of dimeric Se-Se compounds and deselenation reactions of charge-transfer adducts of diiodine | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.primary | DOI 10.1002/chem.200501455 | - |
heal.identifier.secondary | <Go to ISI>://000240387000016 | - |
heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/chem.200501455/asset/6888_ftp.pdf?v=1&t=h0dvl0e1&s=bfc14010c226b3e464d5648e3dd769a9bcfff5a2 | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
heal.publicationDate | 2006 | - |
heal.abstract | Four selenium analogues of the antithyroid drug 6-n-propyl-2-thiouracil (PTU), of formulae RSeU, (R = methyl (Me) (1), ethyl (Et) (2), n-propyl (nPr) (3), and isopropyl (iPr) 4), have been synthesized. Reaction of 1-4 with diiodine in a 1:1 molar ratio in dichloromethane results in the formation of [(RSeU)I(2)] (R = methyl (5), ethyl (6), n-propyl (7) and isopropyl (8)). All compounds have been characterized by elemental analysis, FT-Raman, FT-IR, UV/Vis, (1)H-, (13)C-, (77)Se-1D and -2D NMR spectroscopy, and ESI-MS spectrometric techniques. Recrystallization of 4 from dichloromethane afforded (4 center dot CH(2)Cl(2))- Crystals of [(nPrSeU)I(2)] (7), a charge-transfer complex, were obtained from chloroform solutions, while crystallization of 6 and 7 from acetone afforded the diselenides [N-(6-Et-4-pyrimidone)(6-EtSeU)(2)] (9 center dot 2H(2)O) and [N-(6-nPr-4-pyrimidone)(6-nPrSeU)(2)] (10) as oxidation products. Recrystallization of 7 from methanol/acetonitrile solutions led to deselenation with the formation of 6-n-propyl-2-uracil (nPrU) (11). [(nPrSeU)I(2)] (7) was found to be a charge-transfer complex with a Se-I bond. These results are discussed in relation to the mechanism of action of antithyroid drugs. | en |
heal.publisher | Wiley-VCH Verlag | en |
heal.journalName | Chemistry-a European Journal | en |
heal.journalType | peer reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ |
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Antoniadis-2006-Synthesis and struct.pdf | 206.22 kB | Adobe PDF | View/Open Request a copy |
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