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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/9415
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dc.contributor.authorKokotos, G.en
dc.contributor.authorTheodorou, V.en
dc.contributor.authorConstantinou-Kokotou, V.en
dc.contributor.authorGibbons, W. A.en
dc.contributor.authorRoussakis, C.en
dc.date.accessioned2015-11-24T16:49:02Z-
dc.date.available2015-11-24T16:49:02Z-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9415-
dc.rightsDefault Licence-
dc.subjectlipidic amino-acidsen
dc.subjectprotein-kinase-cen
dc.subjectcyto-toxicityen
dc.subjectcis-dichlorodiammineplatinum(ii)en
dc.subjectpeptidesen
dc.subjectanalogsen
dc.subjectinvitroen
dc.subjectagentsen
dc.subjectgrowthen
dc.subjectcellsen
dc.titleSynthesis and in vitro cytotoxicity of lipophilic platinum(II) complexesen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDoi 10.1016/S0960-894x(98)00256-X-
heal.identifier.secondary<Go to ISI>://000074291800017-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0960894X9800256X/1-s2.0-S0960894X9800256X-main.pdf?_tid=8795a208-3640-11e3-981b-00000aab0f02&acdnat=1381913833_3f9f57069fa93c24ea10aa796c768cb7-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate1998-
heal.abstractA number of lipophilic platinum(II) complexes of the general structures cis-[Pt(LA)(2)Cl-2] and [Pt(LD)Cl-2] were synthesised. Long chain amines (LA) and diamines (LD), prepared from lipidic amino acids, were used as ligands. The in vitro cytotoxicity of the complexes was evaluated against four cell lines (P388, NSCLC-N6, E39, M96). cis-Dichloro-bis(2-aminohexadecanol)platinum(II) was the most active against P388, NSCLC-N6 and E39 (IC50: 11 mu g/ml, 25 mu g/ml, 31 mu g/ml), while dichloro(1,3-heptadecanediamine)platinum presented the highest activity against M96 (IC50: 13 mu g/ml). (C) 1998 Elsevier Science Ltd. All rights reserved.en
heal.publisherElsevieren
heal.journalNameBioorganic and Medicinal Chemistry Lettersen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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