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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Karidi, K. | en |
| dc.contributor.author | Ypsilantis, K. | en |
| dc.contributor.author | Papakyriakou, A. | en |
| dc.contributor.author | Garoufis, A. | en |
| dc.date.accessioned | 2015-11-24T16:48:59Z | - |
| dc.date.available | 2015-11-24T16:48:59Z | - |
| dc.identifier.issn | 0162-0134 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9407 | - |
| dc.rights | Default Licence | - |
| dc.subject | ruthenium | en |
| dc.subject | oligopyridine | en |
| dc.subject | peptide | en |
| dc.subject | conjugates | en |
| dc.subject | oligonucleotide | en |
| dc.subject | DNA-binding properties | en |
| dc.subject | solid-phase synthesis | en |
| dc.subject | deoxynucleotide duplex | en |
| dc.subject | electron-transfer | en |
| dc.subject | enantioselective binding | en |
| dc.subject | molecular-dynamics | en |
| dc.subject | nmr-spectroscopy | en |
| dc.subject | amino-acids | en |
| dc.subject | ruthenium | en |
| dc.subject | complexes | en |
| dc.title | Synthesis and characterization of ruthenium(II)-oligopyridine-peptide conjugates. Interactions of the diasteromeres Delta- and Lambda-[Ru(bpy)(2) (4-COY-4 '-Mebpy)]Cl-2 (Y = Gly-Lys(1)-Lys(2)CONH(2), Lys(1)-Gly-Lys(2)CONH(2), Lys(1)-Lys(2)-GlyCONH(2)) with the oligonucleotide d(5 '-CGCGAATTCGCG-3 ')(2) | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | DOI 10.1016/j.jinorgbio.2013.06.010 | - |
| heal.identifier.secondary | <Go to ISI>://000324661500003 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0162013413001517/1-s2.0-S0162013413001517-main.pdf?_tid=0bff1306-5808-11e3-8775-00000aacb361&acdnat=1385627913_6c113a090ce818398ae18623ac1f8af0 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2013 | - |
| heal.abstract | Diastereomeric complexes of the general formulae Lambda- and Delta-[Ru(bpy)(2)(4-COY-4'-Mebpy)]Cl-2 where bpy = 2,2'-bipyridine and Y = Gly-Lys(1)-Lys(2)CONH(2), Lys(1)-Gly-Lys(2)CONH(2), Lys(1)-Lys(2)-GlyCONH(2), were synthesized and characterized. The ability of these compounds to bind to the oligonucleotide duplex d(5'-CGCGAATTCGCG-3') was studied with NMR techniques. Complex Lambda-2, Lambda-[Ru(bpy)(2)(4-COLys(1)-Gly-Lys(2)CONH(2)),4'-Mebpy)]Cl-2 (Mebpy = methyl-2,2'-bipyridine), interacts non-specifically causing changes for both complex and oligonucleotide H-1 NMR signals. Both Lambda-1, Lambda-[Ru(bpy)(2)(4-COGly-Lys(1)-Lys(2)CONH(2)),4'-Mebpy)]Cl-2 and Lambda-3, Lambda-[Ru(bpy)(2)(4-COLys(1)-Lys(2)-GlyCONH(2)),4'-Mebpy)]Cl-2, were bound to the oligonucleotide through both lysine aliphatic chains, indicating that the side chains of the sequential lysines create a kind of "clamp" to connect the complex with the oligonucleotide. Complex Delta-1, Delta-[Ru(bpy)(2)(4-COGly-Lys(1)-Lys(2)CONH(2)),4'-Mebpy)]Cl-2, interacts with the oligonucleotide duplex with both lysine side chains in a manner similar to Lambda-1. Delta-2, Delta-[Ru(bpy)(2)(4-COLys(1)-Gly-Lys(2)CONH(2)),4'-Mebpy)Cl-2, interacts with the oligonucleotide with the bipyridine ligands. In addition, the formation of a hydrogen bond between the Gly-NH and the carbonyl groups of the oligonucleotide bases was detected. A completely different binding mode was observed for Delta-3 Delta-[Ru(bpy)(2)(4-COLys(1)-Lys(2)-GlyCONH(2)),4'-Mebpy)]Cl-2, which at a ratio of 1:1 ([Ru]/[nucleotide]) opens the oligonucleotide strands. In addition, participation of all three peptidic NH of Delta-3 in hydrogen bonds was observed. (c) 2013 Elsevier Inc. All rights reserved. | en |
| heal.publisher | Elsevier | en |
| heal.journalName | J Inorg Biochem | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Karidi-2013-Synthesis and charac.pdf | 1.32 MB | Adobe PDF | View/Open Request a copy |
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