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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Antoniadis, C. D. | en |
| dc.contributor.author | Corban, G. J. | en |
| dc.contributor.author | Hadjikakou, S. K. | en |
| dc.contributor.author | Hadjiliadis, N. | en |
| dc.contributor.author | Kubicki, M. | en |
| dc.contributor.author | Warner, S. | en |
| dc.contributor.author | Butler, I. S. | en |
| dc.date.accessioned | 2015-11-24T16:48:55Z | - |
| dc.date.available | 2015-11-24T16:48:55Z | - |
| dc.identifier.issn | 1434-1948 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9393 | - |
| dc.rights | Default Licence | - |
| dc.subject | bioinorganic chemistry | en |
| dc.subject | charge transfer | en |
| dc.subject | iodine | en |
| dc.subject | s ligands | en |
| dc.subject | nitrogen heterocycles | en |
| dc.subject | charge-transfer complexes | en |
| dc.subject | ray crystal-structures | en |
| dc.subject | x-ray | en |
| dc.subject | molecular-interactions | en |
| dc.subject | antithyroid drugs | en |
| dc.subject | iodothyronine deiodinase | en |
| dc.subject | iodine monobromide | en |
| dc.subject | diiodine adducts | en |
| dc.subject | ft-raman | en |
| dc.subject | methimazole | en |
| dc.title | Synthesis and characterization of (PTU)I-2 (PTU=6-n-propyl-2-thiouracil) and (CMBZT)I-2 (CMBZT=5-chloro-2-mercaptobenzothiazole) and possible implications for the mechanism of action of anti-thyroid drugs | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | <Go to ISI>://000182708400023 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2003 | - |
| heal.abstract | Direct reaction of 6-n-propyl-2-thiouracil (PTU), a widely used anti-thyroid drug against hyperthyroidism (Graves' disease), or 5-chloro-2-mercaptobenzothiazole (CMBZTH) with iodine in a molar ratio of 1: 1 resulted in the formation of the charge-transfer (CT) complexes [(PTU)12] (1) or [(CMBZT)12] (2). All reactions were carried out in dichloromethane and water solutions. Compounds 1 and 2 were characterized by elemental analyses, FT-Raman, FT-IR, UV/Vis and H-1 NMR spectroscopy. The crystal structures of both complexes were determined by X-ray diffraction at 120(l) K (1) and 293(2) K (2). The charge-transfer nature of the bonds in the adducts 1 and 2 was verified by the lengthening of the I-I bond lengths as compared to the S-I bond lengths and by the characteristic CT bands observed in the UV spectra of the complexes. Compound 1 [(C7H10N2OS)I-2] [monoclinic with space group P2(1)/c and a = 9.8501(7), b = 10.3101(7), c = 12.0287(8) Angstrom, beta = 99.707(6)degrees, Z = 4] consists of a propylthiouracil ligand bonded with an iodine atom through sulfur. Extended intermolecular N-(HO)-O-... contacts link the molecules forming a supramolecular assembly. Compound 2 {(C7H4ClNS2)I-2} {orthorhombic, space group P2(1)2(1)2(1), a = 4.1650(10), b = 9.691(2), c = 28.471(6) Angstrom, Z = 41 consists of a 5-chloro-2-mercaptobenzothiazole ligand bonded with an iodine atom through sulfur. An extended intermolecular linkage via (IH)-H-...-N bonds leads to the formation of an extended structure. Attempts to draw conclusions on the behavior of a thioamide - when used as an anti-thyroidal drug - towards iodine have been made. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003). | en |
| heal.publisher | Wiley | en |
| heal.journalName | European Journal of Inorganic Chemistry | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
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