Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/9193Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Papaioannou, A. | en |
| dc.contributor.author | Manos, M. | en |
| dc.contributor.author | Karkabounas, S. | en |
| dc.contributor.author | Liasko, R. | en |
| dc.contributor.author | Evangelou, A. M. | en |
| dc.contributor.author | Correia, I. | en |
| dc.contributor.author | Kalfakakou, V. | en |
| dc.contributor.author | Pessoa, J. C. | en |
| dc.contributor.author | Kabanos, T. | en |
| dc.date.accessioned | 2015-11-24T16:47:30Z | - |
| dc.date.available | 2015-11-24T16:47:30Z | - |
| dc.identifier.issn | 0162-0134 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9193 | - |
| dc.rights | Default Licence | - |
| dc.subject | vanadium | en |
| dc.subject | cysteine | en |
| dc.subject | antitumor activity | en |
| dc.subject | circular dichroism | en |
| dc.subject | electron paramagnetic resonance | en |
| dc.subject | cysteine methyl-ester | en |
| dc.subject | vanadium complexes | en |
| dc.subject | malignant-tumors | en |
| dc.subject | human-plasma | en |
| dc.subject | wistar rats | en |
| dc.subject | enkephalinase | en |
| dc.subject | oxovanadium(iv) | en |
| dc.subject | crystal | en |
| dc.subject | ligands | en |
| dc.subject | epr | en |
| dc.title | Solid state and solution studies of a vanadium(III)-L-cysteine compound and demonstration of its antimetastatic, antioxidant and inhibition of neutral endopeptidase activities | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | DOI 10.1016/j.jinorgbio.2004.02.011 | - |
| heal.identifier.secondary | <Go to ISI>://000221939000006 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0162013404000479/1-s2.0-S0162013404000479-main.pdf?_tid=e92d71a88a90fbde7a7bb101aee49ee1&acdnat=1333030587_2836120f6674caa0a10d3d8621127930 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2004 | - |
| heal.abstract | Reaction of one equivalent of vanadium(III) chloride with three equivalents Of L-cysteine(H(2)Cys) in methyl alcohol affords a V-III-Cys compound that is formulated as [V-III(HCYS)(3)] . 2HCl . 2.5H(2)O 1. The solid state characterization of 1 was performed by microanalysis, circular dichroism (CD) and infrared studies as well as room temperature magnetic susceptibility. These studies have shown coordination of each HCys(-) ligand to the V-III atom through an amine nitrogen and a carboxylate oxygen atoms. Solution studies of I were carried out in water and methanol by UV visible, CD and electron paramagnetic resonance (EPR) spectroscopies. According to these studies, it was evident that despite the progressive oxidation of 1 to oxovanadium(IV) species, some V(III) species were also present in solution after several hours. Compound 1, (VOSO4)-O-IV.5H(2)O and L-cysteine were examined for their total antioxidant capacity (TAC) and lag time. Compound 1 exhibited significantly greater total antioxidant capacity and lag time values than L-cysteine. (VOSO4)-O-IV.5H(2)O did not show any total antioxidant capacity or lag time. The inhibition of neutral endopeptidase (NEP) activity caused by 1, (VOSO4)-O-IV . 5H(2)O and thiorphan was also measured. Compound 1, at a concentration of 10(-3) M, showed inhibition of NEP activity as potent as thiorphan at 10(-6) M, while (VOSO4)-O-IV . 5H(2)O in the same concentration exhibited less than 50% inhibitory activity than that of thiorphan at 10-6 M. Moreover, the antimetastatic effects of compound 1, L-CySteine and (VOSO4)-O-IV . 5H(2)O were examined on Wistar rats, treated with 3,4-benzopyrene. The results revealed that I prevents significantly lung metastases (only 9.5% of animals treated with 1 showed metastases), whereas 47-52% of the rats of the control group and those treated with L-cysteine and (VOSO4)-O-IV . 5H(2)O exhibited metastases. (C) 2004 Elsevier Inc. All rights reserved. | en |
| heal.publisher | Elsevier | en |
| heal.journalName | J Inorg Biochem | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Papaioannou-2004-Solid state and solu.pdf | 299.77 kB | Adobe PDF | View/Open Request a copy |
This item is licensed under a Creative Commons License
