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https://olympias.lib.uoi.gr/jspui/handle/123456789/9019Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Segerer, H. | en |
| dc.contributor.author | Scheid, A. | en |
| dc.contributor.author | Wagner, M. H. | en |
| dc.contributor.author | Lekka, M. | en |
| dc.contributor.author | Obladen, M. | en |
| dc.date.accessioned | 2015-11-24T16:46:01Z | - |
| dc.date.available | 2015-11-24T16:46:01Z | - |
| dc.identifier.issn | 0006-3126 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9019 | - |
| dc.rights | Default Licence | - |
| dc.subject | respiratory distress syndrome | en |
| dc.subject | surfactant substitution | en |
| dc.subject | instillation method | en |
| dc.subject | pulmonary distribution | en |
| dc.subject | animal model | en |
| dc.subject | platelet-activating factor | en |
| dc.subject | platelet-activating-factor | en |
| dc.subject | respiratory-distress syndrome | en |
| dc.subject | exogenous surfactant | en |
| dc.subject | lung injury | en |
| dc.subject | pulmonary distribution | en |
| dc.subject | artificial surfactant | en |
| dc.subject | preterm infants | en |
| dc.subject | permeability | en |
| dc.subject | volume | en |
| dc.subject | therapy | en |
| dc.title | Rapid tracheal infusion of surfactant versus bolus instillation in rabbits: Effects on oxygenation, blood pressure and surfactant distribution | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | <Go to ISI>://A1996UA92500007 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 1996 | - |
| heal.abstract | Surfactant bolus instillation may be associated with a drop in blood pressure, Platelet-activating factor (PAF) has been found in surfactant preparations. The aim of this study was to evaluate rapid tracheal infusion of surfactant during 5 min as an alternative to bolus instillation and to examine whether a PAF receptor antagonist is able to prevent the decrease in blood pressure. Methods: Surfactant deficiency was induced in 16 adult rabbits by lung lavages with saline. Six animals received a bolus of a porcine surfactant preparation (Curosurf((R)) (CS); 200 mg/kg), labeled with red microspheres to assess pulmonary distribution. In another 5 rabbits, the same amount of labelled CS was instilled by tracheal infusion within 5 min. A third group of 5 animals received 3 mg/kg body weight of the PAF antagonist WEB 2170 before CS bolus instillation. Results: After CS bolus administration, mean PaO2 increased by 44.7 +/- 8.3 kPa (mean +/- SD) within 2 min and remained at this level. Mean arterial blood pressure dropped transiently by 2.3 +/- 2 kPa within 5 min. Pulmonary distribution of surfactant was even. After infusion, mean PaO2 rose by 22.4 +/- 16.3 kPa within 15 min. Blood pressure dropped by 1.8 +/- 1.1 kPa within 15 min. The distribution was extremely uneven. Blood pressure decreases also occurred after pretreatment with PAF receptor antagonist. Conclusion: Rapid tracheal infusion of surfactant results in poorer oxygenation, an inhomogeneous distribution and a similar decrease in blood pressure compared to the bolus instillation method. Blood pressure changes could not be prevented by a PAF receptor-specific antagonist. | en |
| heal.publisher | Karger | en |
| heal.journalName | Biology of the Neonate | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Lekka-1996-Rapid tracheal infusion.pdf | 3.26 MB | Adobe PDF | View/Open Request a copy |
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