Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/8971
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Archimandriti, D. T. | en |
dc.contributor.author | Dalavanga, Y. A. | en |
dc.contributor.author | Cianti, R. | en |
dc.contributor.author | Bianchi, L. | en |
dc.contributor.author | Manda-Stachouli, C. | en |
dc.contributor.author | Armini, A. | en |
dc.contributor.author | Koukkou, A. I. I. | en |
dc.contributor.author | Rottoli, P. | en |
dc.contributor.author | Constantopoulos, S. H. | en |
dc.contributor.author | Bini, L. | en |
dc.date.accessioned | 2015-11-24T16:45:42Z | - |
dc.date.available | 2015-11-24T16:45:42Z | - |
dc.identifier.issn | 1535-3893 | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8971 | - |
dc.rights | Default Licence | - |
dc.subject | metsovo lung | en |
dc.subject | asbestos | en |
dc.subject | tremolite | en |
dc.subject | malignant mesothelioma | en |
dc.subject | pleural calcifications | en |
dc.subject | bronchoalveolar lavage | en |
dc.subject | proteomics | en |
dc.subject | two-dimensional electrophoresis | en |
dc.subject | acid ceramidase | en |
dc.subject | glutathione-s-transferase | en |
dc.subject | malignant pleural mesothelioma | en |
dc.subject | bovine serum-albumin | en |
dc.subject | free-radicals | en |
dc.subject | acid ceramidase | en |
dc.subject | lung-cancer | en |
dc.subject | cell-death | en |
dc.subject | 2-dimensional electrophoresis | en |
dc.subject | hsp27 oligomerization | en |
dc.subject | ca2+-binding protein | en |
dc.title | Proteome Analysis of Bronchoalveolar Lavage in Individuals from Metsovo, Nonoccupationally Exposed to Asbestos | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.primary | Doi 10.1021/Pr800370n | - |
heal.identifier.secondary | <Go to ISI>://000263193300046 | - |
heal.identifier.secondary | http://pubs.acs.org/doi/abs/10.1021/pr800370n | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
heal.publicationDate | 2009 | - |
heal.abstract | Inhabitants of Metsovo, NW Greece, have been exposed to an asbestos whitewash, resulting in malignant pleural mesothelioma (MPM) and pleural calcifications (PCs). Interestingly, those with PCs (PC(+)) are less prone to MPM. They also have lymphocytic alveolitis, and differences in bronchoalveolar lavage (BAL) proteins, compared with those without pleural calcifications (PC(-)). This may mean a different response to the fiber leading to different susceptibility to neoplasia. To further evaluate this, a proteomic analysis of BAL proteins was performed. Proteomic analysis (2D-electrophoresis/Mass Spectrometry) of BAL in Metsovites nonoccupationally exposed to asbestos revealed increased albumin fragments, alpha 1-antitrypsin, S100-A9 and HSP27, suggesting ongoing inflammation. In those without pleural calcifications, increased expression of acid ceramidase, glutathione-S-transferase and presence of calcyphosin, all involved in cell cycle regulation and death as well as in the detoxification of mutagenic and toxic agents, lend further support to our thesis of possible "protection against neoplasia" in Metsovites with pleural calcifications. | en |
heal.publisher | American Chemical Society | en |
heal.journalName | J Proteome Res | en |
heal.journalType | peer reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ |
Files in This Item:
There are no files associated with this item.
This item is licensed under a Creative Commons License