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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Tselepis, A. D. | en |
| dc.contributor.author | Hahalis, G. | en |
| dc.contributor.author | Tellis, C. C. | en |
| dc.contributor.author | Papavasiliou, E. C. | en |
| dc.contributor.author | Mylona, P. T. | en |
| dc.contributor.author | Kourakli, A. | en |
| dc.contributor.author | Alexopoulos, D. C. | en |
| dc.date.accessioned | 2015-11-24T16:44:57Z | - |
| dc.date.available | 2015-11-24T16:44:57Z | - |
| dc.identifier.issn | 0022-2275 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8856 | - |
| dc.rights | Default Licence | - |
| dc.subject | low density lipoprotein | en |
| dc.subject | high density lipoprotein | en |
| dc.subject | oxidative stress | en |
| dc.subject | atherosclerosis | en |
| dc.subject | platelet-activating-factor | en |
| dc.subject | low-density-lipoprotein | en |
| dc.subject | factor-acetylhydrolase activity | en |
| dc.subject | sickle-cell-disease | en |
| dc.subject | paf-acetylhydrolase | en |
| dc.subject | oxidative stress | en |
| dc.subject | coronary atherosclerosis | en |
| dc.subject | endothelial dysfunction | en |
| dc.subject | ldl | en |
| dc.subject | expression | en |
| dc.title | Plasma levels of lipoprotein-associated phospholipase A(2) are increased in patients with beta-thalassemia | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | Doi 10.1194/Jlr.M007229 | - |
| heal.identifier.secondary | <Go to ISI>://000282808200026 | - |
| heal.identifier.secondary | http://www.jlr.org/content/51/11/3331.full.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2010 | - |
| heal.abstract | Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an independent cardiovascular risk factor. We investigated the plasma levels of Lp-PLA(2) activity and mass as a function of plasma lipid levels, LDL subclass profile, and oxidative stress in patients with beta-thalassemia. Thirty-five patients with beta-thalassemia major (beta-TM) and 25 patients with beta-thalassemia intermedia (beta-TI) participated in the study. Lp-PLA(2) activity and mass were measured in total plasma, in apolipoprotein (apo) B-depleted plasma (HDL-Lp- PLA(2)), and in LDL subclasses. Lp-PLA(2) activity produced and secreted from peripheral blood monocytes in culture was also determined. Patients with beta-thalassemia are characterized by a predominance of small-dense LDL particles, increased oxidative stress, and very high plasma levels of Lp-PLA(2) mass and activity, despite low LDL-cholesterol levels. A significant positive correlation between plasma Lp-PLA(2) activity or mass and 8-isoprostane (8-epiPGF2a) and ferritin levels as well as intima-media thickness (IMT) values was observed. An increase in secreted and cell-associated Lp-PLA(2) activity from monocytes in culture was observed in both patient groups. The HDL-Lp-PLA(2) activity and mass as well as the ratio of HDL-Lp-PLA(2)/plasma Lp-PLA(2) were significantly higher in both patient groups compared with the control group. In conclusion, patients with beta-thalassemia exhibit high plasma Lp-PLA(2) levels, attributed to increased enzyme secretion from monocytes/macrophages and to the predominance of sdLDL particles in plasma. Plasma Lp-PLA(2) is correlated with carotid IMT, suggesting that this enzyme may be implicated in premature carotid atherosclerosis observed in beta-thalassemia.-Tselepis, A. D., G. Hahalis, C. C. Tellis, E. C. Papavasiliou, P. T. Mylona, A. Kourakli, and D. C. Alexopoulos. Plasma levels of lipoprotein-associated phospholipase A2 are increased in patients with beta-thalassemia. J. Lipid Res. 2010. 51: 3331-3341. | en |
| heal.publisher | American Society for Biochemistry and Molecular Biology, Inc. | en |
| heal.journalName | Journal of Lipid Research | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Tselepis-2010-Plasma levels of lip.pdf | 1.15 MB | Adobe PDF | View/Open Request a copy |
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