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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/8850
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dc.contributor.authorKontogianni, V. G.en
dc.contributor.authorTomic, G.en
dc.contributor.authorNikolic, I.en
dc.contributor.authorNerantzaki, A. A.en
dc.contributor.authorSayyad, N.en
dc.contributor.authorStosic-Grujicic, S.en
dc.contributor.authorStojanovic, I.en
dc.contributor.authorGerothanassis, I. P.en
dc.contributor.authorTzakos, A. G.en
dc.date.accessioned2015-11-24T16:44:55Z-
dc.date.available2015-11-24T16:44:55Z-
dc.identifier.issn0308-8146-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8850-
dc.rightsDefault Licence-
dc.subjectcancer cell apoptosisen
dc.subjectnitric oxideen
dc.subjectrinm5fen
dc.subjectrosmarinus officinalis extracten
dc.subjectsalvia officinalis extracten
dc.subjectlc-ms/msen
dc.subjecth-1-c-13 hsqc and hmbc nmren
dc.subjectperformance liquid-chromatographyen
dc.subjectin-vitroen
dc.subjectphenolic compositionen
dc.subjectmass-spectrometryen
dc.subjectplant-extractsen
dc.subjectursolic aciden
dc.subjectcancer-cellsen
dc.subjectsageen
dc.subjectapoptosisen
dc.subjectrosemaryen
dc.titlePhytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activityen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1016/j.foodchem.2012.07.091-
heal.identifier.secondary<Go to ISI>://000309897000018-
heal.identifier.secondaryhttp://ac.els-cdn.com/S030881461201206X/1-s2.0-S030881461201206X-main.pdf?_tid=29b1dc4e-3247-11e3-b83f-00000aab0f6b&acdnat=1381476877_16d6a6e9befd80cf44189370eb7850ee-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate2013-
heal.abstractThe goal of this study was to monitor the anti-proliferative activity of Rosmarinus officinalis and Salvia officinalis extracts against cancer cells and to correlate this activity with their phytochemical profiles using liquid chromatography/diode array detection/electrospray ion trap tandem mass spectrometry (LC/DAD/ESI-MSn). For the quantitative estimation of triterpenic acids in the crude extracts an NMR based methodology was used and compared with the HPLC measurements, both applied for the first time, for the case of betulinic acid. Both extracts exerted cytotoxic activity through dose-dependent impairment of viability and mitochondrial activity of rat insulinoma m5F (RINm5F) cells. Decrease of RINm5F viability was mediated by nitric oxide (NO)-induced apoptosis. Importantly, these extracts potentiated NO and TNF-alpha release from macrophages therefore enhancing their cytocidal action. The rosemary extract developed more pronounced antioxidant, cytotoxic and immunomodifying activities, probably due to the presence of betulinic acid and a higher concentration of carnosic acid in its phytochemical profile. (C) 2012 Elsevier Ltd. All rights reserved.en
heal.publisherElsevieren
heal.journalNameFood Chemistryen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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