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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/8722
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dc.contributor.authorChasapis, C. T.en
dc.contributor.authorHadjikakou, S. K.en
dc.contributor.authorGaroufis, A.en
dc.contributor.authorHadjiliadis, N.en
dc.contributor.authorBakas, T.en
dc.contributor.authorKubicki, M.en
dc.contributor.authorMing, Y.en
dc.date.accessioned2015-11-24T16:43:38Z-
dc.date.available2015-11-24T16:43:38Z-
dc.identifier.issn1565-3633-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8722-
dc.rightsDefault Licence-
dc.subjectbioinorganic chemistryen
dc.subjectorganotin(iv) compoundsen
dc.subjectmercapto amino acidsen
dc.subjectl-cysteineen
dc.subjectanti-tumour compoundsen
dc.subjectacetyl-l-cysteineen
dc.subjectamino-acidsen
dc.subjectcrystal-structureen
dc.subjectethyl-esteren
dc.subjectcomplexesen
dc.subjecttinen
dc.subjectpenicillamineen
dc.subjectmethionineen
dc.subjectligandsen
dc.titleOrganotin(IV) derivatives of L-cysteine and their in vitro anti-tumor propertiesen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1155/S1565363304000044-
heal.identifier.secondary<Go to ISI>://000224303000004-
heal.identifier.secondaryhttp://downloads.hindawi.com/journals/bca/2004/418579.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate2004-
heal.abstractThe synthesis and characterization of the organotin compounds [(n-C4H9)(2)Sn(cys)] (1), [(C6H5)(2)Sn(cys)] (2), [(C6H5)(3)Sn(Hcys).(H2O)] (3), {[(CH3)(2)Sn(KCYS)(2)].2(H2O)} (4), {[(n-C4H9)(2)Sn(KCYS)(2)].2(H2O)} (5) and {[(C6H5)(2)Sn(KCYS)(2)].2(H2O)} (6) (where H(2)cys= L-cysteine) are reported. The compounds have been characterized by elemental analysis and H-1-NMR, Uv-Vis, FT-IR and Mossbauer spectroscopic techniques. Attempted recrystallization of (2) in DMSO/methanol 2:1 solution yielded after several days unexpectedly the dimeric compound bis(tri-phenyltin)sulphide {[(C6H5)(3)Sn](2)S} (7) which has been characterized by x-ray analysis. The structure of the parent complex (2) as well as the mechanism of the decomposition of cysteine are being further investigated. The in vitro anticancer activity of complexes (1) - (6), against human leukemia (HL60), human liver (Bel7402), human stomach (BGC823) and human cervix epithelial human carcinoma (Hela), nasopharyngeal carcinoma (KB) and lung cancer (PG) tumor cells, were evaluated.en
heal.publisherFreund Publishing House Ltd.en
heal.journalNameBioinorg Chem Applen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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