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dc.contributor.authorMalandrinos, G.en
dc.contributor.authorLouloudi, M.en
dc.contributor.authorMitsopoulou, C. A.en
dc.contributor.authorButler, I. S.en
dc.contributor.authorBau, R.en
dc.contributor.authorHadjiliadis, N.en
dc.date.accessioned2015-11-24T16:43:13Z-
dc.date.available2015-11-24T16:43:13Z-
dc.identifier.issn0949-8257-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8668-
dc.rightsDefault Licence-
dc.subjectthiaminen
dc.subjectthiamin metal complexesen
dc.subjectspectroscopic characterizationen
dc.subjectthiamin catalysisen
dc.subjectdiphosphate dependent enzymeen
dc.subjecttransketolaseen
dc.subjectresolutionen
dc.subjecthydrochlorideen
dc.subjectspectroscopyen
dc.subjectvitamin-b-1en
dc.subjectderivativesen
dc.subjectchlorideen
dc.subjectzn2+en
dc.subjectcd2+en
dc.titleOn the mechanism of action of thiamin enzymes, crystal structure of 2-(alpha-hydroxyethyl)thiamin pyrophosphate (HETPP). Complexes of HETPP with zinc(II) and cadmium(II)en
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1007/s007750050253-
heal.identifier.secondary<Go to ISI>://000076617900001-
heal.identifier.secondaryhttp://download.springer.com/static/pdf/41/art%253A10.1007%252Fs007750050253.pdf?auth66=1382078775_06f477b5d7e7fa4b84148895f51c5be6&ext=.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate1998-
heal.abstractThe crystal structure of the 2-(alpha-hydroxethyl) thiamin pyrophosphate (LH2) was solved by X-ray diffraction. Crystallographic data: space group F2dd, a = 7.922(4) Angstrom, b = 33.11(2) Angstrom, c = 36.232(10) Angstrom, V = 9503(9) Angstrom(3), z = 16. Metal complexes of the general formula K-2{[M(LH)Cl-2](2)} (M = Zn2+, Cd2+) were isolated from methanolic solutions and characterized by elemental analysis, IR, Raman, and C-13 CP MAS NMR spectra. They were also characterized by C-13 NMR, P-31 NMR, Cd-113 NMR, ES-MS, and H-1 NMR ROESY spectra in D2O solutions. The data provide evidence for the bonding of the metals to the N(1') atom of the pyrimidine ring and to the pyrophosphate group. The free ligand and the metal-coordinated ligand adopt the S conformation. Since thiamin cofactor, substrate, and metal ions are present in our system, the extracted results directly refer to thiamin catalysis and possible functional implications are correlated and discussed.en
heal.publisherSpringer Verlag (Germany)en
heal.journalNameJournal of Biological Inorganic Chemistryen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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