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dc.contributor.authorApostolou, F.en
dc.contributor.authorGazi, I. F.en
dc.contributor.authorLagos, K.en
dc.contributor.authorTellis, C. C.en
dc.contributor.authorTselepis, A. D.en
dc.contributor.authorLiberopoulos, E. N.en
dc.contributor.authorElisaf, M.en
dc.rightsDefault Licence-
dc.subjectepstein-barr virusen
dc.subjectsmall-dense ldl particlesen
dc.subjectlipoprotein-associated phospholipase a(2) (lp-pla(2))en
dc.subjectactivating-factor acetylhydrolaseen
dc.subjectacute-phase responseen
dc.subjectserum paraoxonase-1 activityen
dc.subjectmessenger-rna levelsen
dc.subjectphospholipase a(2)en
dc.subjectldl particlesen
dc.subjecthuman plasmaen
dc.titleAcute infection with Epstein-Barr virus is associated with atherogenic lipid changesen
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1016/j.atherosclerosis.2010.06.006-
heal.identifier.secondary<Go to ISI>://000282678500043-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.abstractObjective: To evaluate the effects of acute infection with Epstein-Barr virus (infectious mononucleosis, IM) on lipids and lipoproteins. Methods: Fasting serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs), apolipoproteins (apo) A-I, B, E, C-II, C-III and lipoprotein (a) [Lp(a)] were determined in patients with IM on diagnosis and 4 months after the resolution of febrile illness and in age-and sex-matched controls. Activities of cholesteryl-ester transfer protein (CETP), lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and paraoxonase 1 (PON1) as well as levels of several cytokines were determined. LDL subclass analysis was performed with the Lipoprint LDL System. Results: Twenty-nine patients (16 males, aged 24.3 perpendicular to 14.6 years) and 30 controls were included. TC, HDL-C, LDL-C, apoA-I, apoB, apoC-III and Lp(a) levels were lower at baseline whereas apoB/apoA-I ratio, TG levels and CETP activity were elevated compared with 4 months later. At baseline, higher levels in cytokines and the cholesterol concentration of small-dense LDL particles (sdLDL-C) were noticed, whereas LDL particle size was lower compared with follow-up. Activities of Lp-PLA(2) and PON1 were similar at baseline and 4 months later. Four months after the resolution of IM levels of TGs, apoE, apoC-III, Lp(a), sdLDL-C and cytokines as well as LDL particle size, apoB/apoA-I ratio, CETP and Lp-PLA(2) activities were similar to controls. PON1 activities both at baseline and 4 months later were lower in patients compared with controls. Conclusions: IMis associated with atherogenic changes of lipids and lipoproteins that are partially restored 4 months after its resolution. (C) 2010 Elsevier Ireland Ltd. All rights reserved.en
heal.journalTypepeer reviewed-
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