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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Papadopoulos, M. | en |
| dc.contributor.author | Nock, B. | en |
| dc.contributor.author | Maina, T. | en |
| dc.contributor.author | Pirmettis, I. | en |
| dc.contributor.author | Raptopoulou, C. | en |
| dc.contributor.author | Tasiopoulos, A. | en |
| dc.contributor.author | Troganis, A. | en |
| dc.contributor.author | Kabanos, T. | en |
| dc.contributor.author | Terzis, A. | en |
| dc.contributor.author | Chiotellis, E. | en |
| dc.date.accessioned | 2015-11-24T16:42:53Z | - |
| dc.date.available | 2015-11-24T16:42:53Z | - |
| dc.identifier.issn | 0949-8257 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8614 | - |
| dc.rights | Default Licence | - |
| dc.subject | rhenium | en |
| dc.subject | technetium | en |
| dc.subject | technetium-99m agent | en |
| dc.subject | brain perfusion | en |
| dc.subject | retention mechanism | en |
| dc.subject | technetium-99m l,l-ecd | en |
| dc.subject | rhenium(v) | en |
| dc.subject | perfusion | en |
| dc.subject | ligands | en |
| dc.subject | ecd | en |
| dc.title | Novel lipophilic amidate oxorhenium and oxotechnetium complexes as potential brain agents: Synthesis, characterization and biological evaluation | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | <Go to ISI>://000167176900007 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/74nv1c7q1mpun9p9/fulltext.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2001 | - |
| heal.abstract | Novel oxorhenium and oxotechnetium complexes based on the tetradentate 1-(2-hydroxybenzamido)-2-(pyridinecarboxamido)benzene, H3L, ligand have been synthesized and characterized herein. Thus, by reacting equimolar quantities of the triply deprotonated ligand L3- With the suitable MO3+ precursor, the following neutral MOL complexes could be easily produced following similar synthetic routes: M=Re (1), M=(TC)-T-99g (2) and M=Tc-99m (3). Complexes 1 and 2, prepared in macroscopic amounts, were chemically characterized and their structure determined by single-crystal X-ray analysis. They are isostructural metal chelates, adopting a distorted square pyramidal geometry around the metal. The N3O donor atom set of the tetradentate ligand defines the basal plane and the oxygen atom of the M=O core occupies the apex of the pyramid. Complex 3 forms quantitatively at tracer level by mixing the H3L ligand with (NaTcO4)-Tc-99m generator eluate in aqueous alkaline media and using tin chloride as reductant in the presence of citrate. Its structure was established by chromatographic comparison with prototypic complexes 1 and 2 using high-performance liquid chromatographic techniques. When challenged with excess glutathione in vitro, complex 3 is rapidly converted to hydrophilic unidentified metal species. Tissue distribution data after administration of complex 3 in vivo revealed a significant uptake and retention of this compound in brain tissue. | en |
| heal.publisher | Springer Verlag (Germany) | en |
| heal.journalName | Journal of Biological Inorganic Chemistry | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Papadopoulos-2001-Novel lipophilic ami.pdf | 104.78 kB | Adobe PDF | View/Open Request a copy |
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