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https://olympias.lib.uoi.gr/jspui/handle/123456789/8610Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Rotas, G. | en |
| dc.contributor.author | Natchkebia, K. | en |
| dc.contributor.author | Natsvlishvili, N. | en |
| dc.contributor.author | Kekelidze, M. | en |
| dc.contributor.author | Kimbaris, A. | en |
| dc.contributor.author | Varvounis, G. | en |
| dc.contributor.author | Mikeladze, D. | en |
| dc.date.accessioned | 2015-11-24T16:42:52Z | - |
| dc.date.available | 2015-11-24T16:42:52Z | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8610 | - |
| dc.rights | Default Licence | - |
| dc.subject | pyrrolobenzodiazepine | en |
| dc.subject | neuronal/glial cells | en |
| dc.subject | transformed | en |
| dc.subject | jurkat cells | en |
| dc.subject | DNA cleavage | en |
| dc.subject | anticancer drugs | en |
| dc.subject | DNA-binding | en |
| dc.subject | anthramycin | en |
| dc.subject | damage | en |
| dc.subject | apoptosis | en |
| dc.subject | adducts | en |
| dc.title | Action of a novel pyrrolo[1,2-c][1.3]benzodiazepine on the viability of Jurkat and neuronal/glial cells | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | DOI 10.1016/j.bmcl.2005.05.006 | - |
| heal.identifier.secondary | <Go to ISI>://000230062300009 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0960894X05005652/1-s2.0-S0960894X05005652-main.pdf?_tid=dabb64b2-34ac-11e3-8bbd-00000aab0f26&acdnat=1381740456_449d658683f80f144b0232a8c2290084 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2005 | - |
| heal.abstract | We have designed and synthesized several structural isomers of anthramycin (heterocycles 2, 3, 5, 6, and 8) and found that, in particular, pyrrolobenzodiazepine 8 induces DNA cleavage and formation of small fragments of DNA. The cytotoxic effects of 8 were manifested with both non-transformed primary neuronal/glial cells and transformed Jurkat cells. The other compounds did not change the viability either of transformed or of non-transformed cells, and induced DNA cleavage to a lesser extent. (c) 2005 Elsevier Ltd. All rights reserved. | en |
| heal.publisher | Elsevier | en |
| heal.journalName | Bioorganic and Medicinal Chemistry Letters | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Rotas-2005-Action of a novel py.pdf | 162.88 kB | Adobe PDF | View/Open Request a copy |
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