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DC Field | Value | Language |
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dc.contributor.author | Keramisanou, D. | en |
dc.contributor.author | Tsikaris, V. | en |
dc.contributor.author | Sakarellos-Daitsiotis, M. | en |
dc.contributor.author | Sakarellos, C. | en |
dc.contributor.author | Mikhailova, A. A. | en |
dc.contributor.author | Strelkov, L. A. | en |
dc.date.accessioned | 2015-11-24T16:42:24Z | - |
dc.date.available | 2015-11-24T16:42:24Z | - |
dc.identifier.issn | 1397-002X | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8545 | - |
dc.rights | Default Licence | - |
dc.subject | cell differentiation process and myelopeptides | en |
dc.subject | myelopeptides | en |
dc.subject | myelopeptides conjugated to the sequential oligopeptide carriers | en |
dc.subject | nuclear magnetic resonance of myelopeptides | en |
dc.subject | glycopeptide dendrimers | en |
dc.subject | antigenic peptides | en |
dc.subject | epitope analogs | en |
dc.subject | differentiation | en |
dc.subject | autoantigen | en |
dc.subject | antibody | en |
dc.title | Multiple anchoring of myelopeptides on sequential oligopeptide carriers (SOCn): synthesis, conformation and studies in human leukemia cells | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.secondary | <Go to ISI>://000177951100005 | - |
heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1034/j.1399-3011.2002.21017.x/asset/j.1399-3011.2002.21017.x.pdf?v=1&t=h0e0m5jy&s=14f49c3551a6ae422028497b0047a2619ad0bf52 | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
heal.publicationDate | 2002 | - |
heal.abstract | Myelopeptides, MP-6 (Val-Asp-Pro-Pro) and MP-4 (Phe-Arg-Pro-Arg-Ile-Met-Thr-Pro), induce metabolic changes in human leukemia cells, HL-60, characteristic of the differentiation process, which should be regarded as a promising therapeutic approach in cancer and related diseases. With the aim to optimize the differentiation effect of MPs, they were coupled to the Lys-(NH2)-H-epsilon groups of a sequential oligopeptide carrier Ac-(Lys-Aib-Gly)(4), SOC4, and the constructs obtained were studied. The rigid 3(10) secondary structure of the carrier is preserved even after linkage of the MPs, which also maintain their initial conformations without interacting either with each other or with the carrier, as demonstrated by H-1 nuclear magnetic resonance (NMR) spectroscopy. It is concluded that the carrier accommodates the presentation of MPs, thus improving their differentiation effect on human leukemia cells. | en |
heal.publisher | Blackwell Munksgaard | en |
heal.journalName | Journal of Peptide Research | en |
heal.journalType | peer reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ |
Files in This Item:
File | Description | Size | Format | |
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Keramisanou-2002-Multiple anchoring o.pdf | 218.05 kB | Adobe PDF | View/Open Request a copy |
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