Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/8374
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dc.contributor.authorRizos, E.en
dc.contributor.authorTambaki, A. P.en
dc.contributor.authorGazi, I.en
dc.contributor.authorTselepis, A. D.en
dc.contributor.authorElisaf, M.en
dc.date.accessioned2015-11-24T16:41:09Z-
dc.date.available2015-11-24T16:41:09Z-
dc.identifier.issn0952-3278-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8374-
dc.rightsDefault Licence-
dc.subjectcoronary-heart-diseaseen
dc.subjectactivating-factor-acetylhydrolaseen
dc.subjecttype-2 diabetes-mellitusen
dc.subjectserum paraoxonase activityen
dc.subjectlow-density-lipoproteinen
dc.subjectphospholipase a(2)en
dc.subjectartery-diseaseen
dc.subjectatherosclerosisen
dc.subjectrisken
dc.subjecthyperinsulinemiaen
dc.titleLipoprotein-associated PAF-acetylhydrolase activity in subjects with the metabolic syndromeen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1016/j.plefa.2004.10.021-
heal.identifier.secondary<Go to ISI>://000226946300008-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0952327804001851/1-s2.0-S0952327804001851-main.pdf?_tid=ea09d18fce1b17a439304a36f8eff4d1&acdnat=1333111774_cf7ffbdfe8f88905c2ca24da60933672-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate2005-
heal.abstractPlasma- and lipoprotein-associated activity of the platelet activating factor acetylhydrolase (PAF-acetylhydrolase, PAF-AH) plays an important role in inflammation and in atherosclerotic process, which are present in the metabolic syndrome (MS). Paraoxonase 1 (PON1) is an esterase associated with high-density lipoprotein (HDL) which contributes to the anti-atherogenic effects of this lipoprotein. We investigated the activities of both enzymes in 60 patients with MS and 110 age- and sex-matched subjects without it (non-MS group). Plasma PAF-AH activity was higher in the MS compared to the non-MS group, while HDL-PAF-AH and serum PON1 activities were lower in the MS compared to the non-MS group. Univariate regression analysis in the MS group showed that plasma PAF-AH activity was positively associated with systolic blood pressure, whereas HDL-PAF-AH activity was inversely associated with the homeostasis model assessments (HOMA) index. Both associations remained significant in the multivariate regression analysis, suggesting that insulin resistance and systolic hypertension are major determinants for the alterations in plasma and HDL-associated PAF-AH activity among those observed in MS patients. (C) 2004 Elsevier Ltd. All rights reserved.en
heal.journalNameProstaglandins Leukotrienes and Essential Fatty Acidsen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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