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DC Field | Value | Language |
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dc.contributor.author | Kiortsis, D. N. | en |
dc.contributor.author | Tsouli, S. | en |
dc.contributor.author | Lourida, E. S. | en |
dc.contributor.author | Xydis, V. | en |
dc.contributor.author | Argyropoulou, M. I. | en |
dc.contributor.author | Elisaf, M. | en |
dc.contributor.author | Tselepis, A. D. | en |
dc.date.accessioned | 2015-11-24T16:40:56Z | - |
dc.date.available | 2015-11-24T16:40:56Z | - |
dc.identifier.issn | 0003-3197 | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8335 | - |
dc.rights | Default Licence | - |
dc.subject | platelet-activating-factor | en |
dc.subject | coronary-heart-disease | en |
dc.subject | cardiovascular risk-factors | en |
dc.subject | arterial-wall thickness | en |
dc.subject | low-density-lipoprotein | en |
dc.subject | c-reactive protein | en |
dc.subject | atherosclerosis risk | en |
dc.subject | phospholipase a(2) | en |
dc.subject | insulin-resistance | en |
dc.subject | diabetes-mellitus | en |
dc.title | Lack of association between carotid intima-media thickness and PAF-acetylhydrolase mass and activity in patients with primary hyperlipidemia | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.secondary | <Go to ISI>://000230801100013 | - |
heal.identifier.secondary | http://ang.sagepub.com/content/56/4/451.full.pdf | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
heal.publicationDate | 2005 | - |
heal.abstract | Carotid intima media thickness (IMT), represents an important clinical indicator of early atherosclerosis. Human plasma platelet-activating factor acety1hydrolase (PAF-AH) is an enzyme primarily associated with low-density lipoprotein (LDL) while a small proportion of enzymatic activity is also associated with high-density lipoprotein (HDL). Plasma paraoxonase 1 (PON 1) is an esterase exclusively associated with HDL. The authors investigated the possible relationship between carotid IMT and the plasma levels of PAF-AH mass and activity as well as the PON 1 activity in hyperlipiclemic patients. One hundred unrelated patients with primary hyperlipidemia and 67 age- and sex-matched normolipidemic apparently healthy volunteers participated in the study. The PAF-AH activity in total plasma and in HDL-rich plasma (HDL-PAF-AH activity), the plasma PAF-AH mass, and the serum PON I activities toward paraoxon and phenyl acetate were determined. The plasma PAF-AH mass and activity were higher in hyperlipidemic patients compared to controls, whereas the HDL-PAF-AH activity, as well as the serum PON I activities were not significantly different between the studied groups. When hyperlipidemic patients were divided into 2 subgroups according to their IMT values (IMT < 0.7 mm and IMT >= 0.7 mm) patients with IMT >= 0.7 mm had significantly higher age, and serum triglycericle concentrations, whereas no difference was found in the plasma PAF-AH mass and activity as well as in the HDL-PAF-AH activity between the 2 studied subgroups. The same phenomenon was observed for serum PON1 activities. In a multivariate analysis, only the age was significantly correlated with IMT values (p < 0.05). Neither the total plasma PAF-AH mass and activity nor the HDL-PAF-AH activity are associated with early carotid atherosclerosis. | en |
heal.journalName | Angiology | en |
heal.journalType | peer reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ |
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Kiortsis-2005-Lack of association.pdf | 69.52 kB | Adobe PDF | View/Open Request a copy |
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