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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/8172
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dc.contributor.authorKovala-Demertzi, D.en
dc.contributor.authorPapageorgiou, A.en
dc.contributor.authorPapathanasis, L.en
dc.contributor.authorAlexandratos, A.en
dc.contributor.authorDalezis, P.en
dc.contributor.authorMiller, J. R.en
dc.contributor.authorDemertzis, M. A.en
dc.date.accessioned2015-11-24T16:39:35Z-
dc.date.available2015-11-24T16:39:35Z-
dc.identifier.issn0223-5234-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8172-
dc.rightsDefault Licence-
dc.subjectplatinum(ii) complexesen
dc.subjectthiosemicarbazonato complexesen
dc.subjectcrystal structureen
dc.subjectin vitro and in vivo antitumor activityen
dc.subjectbiological evaluationen
dc.subjectpalladium(ii) complexesen
dc.subjectspectral propertiesen
dc.subject4n-ethyl thiosemicarbazoneen
dc.subjectbiological-activityen
dc.subjectderivativesen
dc.subjectantifungalen
dc.subjectassayen
dc.titleIn vitro and in vivo antitumor activity of platinum(II) complexes with thiosemicarbazones derived from 2-formyl and 2-acetyl pyridine and containing ring incorporated at N(4)-position: Synthesis, spectroscopic study and crystal structure of platinum(II) complexes with thiosemicarbazones, potential anticancer agentsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1016/j.ejmech.2008.08.007-
heal.identifier.secondary<Go to ISI>://000264558600043-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0223523408003656/1-s2.0-S0223523408003656-main.pdf?_tid=6f56cc5ddf3232eab4924563afc11c7f&acdnat=1333028802_b848f61872e659f14a9e78e239ff2319-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate2009-
heal.abstractReactions of thiosemicarbazones of 2-formyl and 2-acetyl pyridine and containing an azepane ring (hexamethyleneiminyl ring) incorporated at N(4)-position, HL(1) (1) and HL(2) (2) with platinum(II) afforded the complexes, [Pt(L(1))Cl] (3) and [Pt(L(2))Cl] (4). Characterization of the compounds was accomplished by means of elemental analysis and spectroscopic techniques NMR, UV-vis and IR spectroscopy. The single-crystal X-ray structure of complex [Pt(L(2))Cl] (4) shows that the ligand monoanion coordinates in a planar conformation to the metal via the pyridyl N atom, the imine-N atom, and thiolato S-atom. Compounds 1-4 have been evaluated for antiproliferative activity in vitro against three human cancer cell lines: MCF-7 (human breast cancer cell line), T24 (bladder cancer cell line), A-549 (non-small cell lung carcinoma) and a mouse L-929 (a fibroblast-like cell line cloned from strain L). Ligand 2 exhibited high activity as anticancer agent against all four cancer cell lines, while ligand 1 exhibited selectivity against MCF-7, L-929 cell lines and complex 4 against A-549, T-24 cancer cell lines. Also, the acute toxicity and antitumor activity were evaluated on leukemia P388-bearing mice. Complex 3 afforded five to six cures against leukemia P388. The in vivo results of the antitumor activity show the two platinum complexes as very effective chemotherapeutic antileukemic agents. (C) 2008 Elsevier Masson SAS. All rights reserved.en
heal.journalNameEur J Med Chemen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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