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https://olympias.lib.uoi.gr/jspui/handle/123456789/7819Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Bonin, R. P. | en |
| dc.contributor.author | Labrakakis, C. | en |
| dc.contributor.author | Eng, D. G. | en |
| dc.contributor.author | Whissell, P. D. | en |
| dc.contributor.author | De Koninck, Y. | en |
| dc.contributor.author | Orser, B. A. | en |
| dc.date.accessioned | 2015-11-24T16:34:34Z | - |
| dc.date.available | 2015-11-24T16:34:34Z | - |
| dc.identifier.issn | 1872-6623 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/7819 | - |
| dc.rights | Default Licence | - |
| dc.subject | Action Potentials/drug effects/genetics | en |
| dc.subject | Analgesics/*pharmacology | en |
| dc.subject | Anesthetics/pharmacology | en |
| dc.subject | Animals | en |
| dc.subject | Bicuculline/pharmacology | en |
| dc.subject | Desoxycorticosterone/analogs & derivatives/pharmacology | en |
| dc.subject | Dose-Response Relationship, Drug | en |
| dc.subject | Electric Stimulation | en |
| dc.subject | Formaldehyde | en |
| dc.title | Pharmacological enhancement of delta-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1016/j.pain.2011.02.011 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21396779 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0304395911001175/1-s2.0-S0304395911001175-main.pdf?_tid=0ebf543a-c388-11e2-88ea-00000aacb362&acdnat=1369300170_06437cf77a53174d1a8a794a0727d93d | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0304395911001175/1-s2.0-S0304395911001175-main.pdf?_tid=16d6bb7c-c388-11e2-8905-00000aacb35d&acdnat=1369300184_46c0684974189b48cfcbaab6527d49a5 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
| heal.publicationDate | 2011 | - |
| heal.abstract | The development of new strategies for the treatment of acute pain requires the identification of novel nonopioid receptor targets. This study explored whether delta-subunit-containing GABA(A)Rs (deltaGABA(A)Rs) in neurons of the spinal cord dorsal horn generate a tonic inhibitory conductance in vitro and whether deltaGABA(A)R activity regulates acute nociception. Whole-cell recordings revealed that deltaGABA(A)Rs generate a tonic inhibitory conductance in cultured spinal neurons and lamina II neurons in spinal cord slices. Increasing deltaGABA(A)R function by applying the deltaGABA(A)R-preferring agonist 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol (THIP) increased the tonic current and inhibited neuronal excitability in spinal neurons from wild-type (WT) but not delta subunit null-mutant (Gabrd(-/-)) mice. In behavioral studies, baseline deltaGABA(A)R activity did not regulate acute nociception; however, THIP administered intraperitoneally or intrathecally attenuated acute nociception in WT but not Gabrd(-/-) mice. In the formalin nociception assay, the phase 1 response was similar for WT and Gabrd(-/-) mice. In contrast, the phase 2 response, which models central sensitization, was greater in Gabrd(-/-) mice than WT. THIP administered intraperitoneally or intrathecally inhibited phase 1 responses of WT but not Gabrd(-/-) mice and had no effect on phase 2 responses of WT mice. Surprisingly, THIP reduced the enhanced phase 2 response in Gabrd(-/-) mice. Together, these results suggest that deltaGABA(A)Rs in spinal neurons play a major physiological and pharmacological role in the regulation of acute nociception and central sensitization. Spinal delta-subunit-containing GABA(A) receptors were identified with electrophysiological methods and behavioral models as novel targets for the treatment of acute pain. | en |
| heal.journalName | Pain | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Bonin-2011-Pharmacological enha1.pdf | 970.67 kB | Adobe PDF | View/Open Request a copy |
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