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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/7784
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dc.contributor.authorThyphronitis, G.en
dc.contributor.authorKinoshita, T.en
dc.contributor.authorInoue, K.en
dc.contributor.authorSchweinle, J. E.en
dc.contributor.authorTsokos, G. C.en
dc.contributor.authorMetcalf, E. S.en
dc.contributor.authorFinkelman, F. D.en
dc.contributor.authorBalow, J. E.en
dc.date.accessioned2015-11-24T16:34:16Z-
dc.date.available2015-11-24T16:34:16Z-
dc.identifier.issn0022-1767-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7784-
dc.rightsDefault Licence-
dc.subjectmurine lymphocytes-ben
dc.subjectmonoclonal-antibodiesen
dc.subjectimmune-responseen
dc.subjecttype-1 cr-1en
dc.subjectc3ben
dc.subjectcellsen
dc.subjectactivationen
dc.subjectsurfaceen
dc.subjectantigenen
dc.subjectlipopolysaccharideen
dc.titleModulation of Mouse Complement Receptor-1 and Receptor-2 Suppresses Antibody-Responses Invivoen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondary<Go to ISI>://A1991FT76300033-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.publicationDate1991-
heal.abstractA mAb, 7G6, that binds to mouse CR1 and CR2 and down-modulates their expression on splenic B cells in vivo, was used to determine whether a decrease in CR1 and CR2 expression affects antibody responses to different T-dependent and T-independent Ag. Injection of mice with the mAb 7G6 prior to immunization with FITC haptenated Salmonella typhimurium (SH5771), Salmonella montevideo (SH5770), SRBC, or Ficoll dramatically decreased subsequent antibody responses to FITC. Although both IgM and IgG primary antibody responses were affected similarly, the antibody levels were most inhibited during early phases of the response. In contrast, down-modulation of the CR did not affect memory antibody responses, because injection of mice with 7G6 before a second immunization with FITC-SH5771 had no effect on subsequent anti-FITC antibody production. Moreover, polyclonal in vivo activation of the mouse immune system by antimouse IgD antibodies was not affected by previous administration of 7G6, because anti-IgD-induced increases in Ia expression and serum IgG1 levels were not affected. Taken together, these observations suggest that CRI and CR2 may play an important role in enhancing primary antibody responses to many T-dependent and T-independent Ag and may contribute to a host's response to naturally occurring antigens such as bacteria.en
heal.journalNameJournal of Immunologyen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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