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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Tsokos, G. C. | en |
| dc.contributor.author | Kinoshita, T. | en |
| dc.contributor.author | Thyphronitis, G. | en |
| dc.contributor.author | Patel, A. D. | en |
| dc.contributor.author | Dickler, H. B. | en |
| dc.contributor.author | Finkelman, F. D. | en |
| dc.date.accessioned | 2015-11-24T16:34:04Z | - |
| dc.date.available | 2015-11-24T16:34:04Z | - |
| dc.identifier.issn | 0022-1767 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/7750 | - |
| dc.rights | Default Licence | - |
| dc.title | Interactions between Murine Lymphocyte-B Surface-Membrane Molecules - Loaded but Not Free Receptors for Complement and the Fc Portion of Igg Co-Cap Independently with Cross-Linked Surface Ig | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | <Go to ISI>://A1990CG62300034 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
| heal.publicationDate | 1990 | - |
| heal.abstract | We have investigated the possible physical interactions between CR, receptors for the Fc gamma R and surface Ig (sIg) on the surface membrane of murine B lymphocytes. We used the rat mAb to murine CR, 8C12, and 7G6, as CR ligands, and soluble Ag-antibody complexes as FcR ligands; and F(ab')2 fragments of rabbit antibodies specific for mouse IgM and IgD as sIg ligands. We have found that: 1) sIg, CR, and Fc gamma R are not directly linked, because capping of any one did not affect the expression of the others; 2) the mAb 8C12 and 7G6 failed by themselves to cross-link CR; 3) soluble Ag-antibody complexes crosslinked some, Fc gamma R on a minority of Fc gamma R+ lymphocytes; 4) once loaded with anti-CR mAb, CR co-capped with sIg when sIg was cross-linked; 5) once loaded with Ag-antibody complexes, Fc gamma R also co-capped with sIg when sIg was sIg was cross-linked; 6) loading of Fc gamma R did not affect the co-capping of surface CR with cross- linked sIg and conversely, loading of CR did not affect the co-capping of Fc gamma R with cross-linked sIg; only loaded CR or Fc gamma R co- capped with sIg regardless of the status of the other surface molecule; 7) neither loaded nor free CR co-capped with cross-linked Fc gamma R, and neither loaded nor free Fc gamma R co-capped with cross-linked CR. These results demonstrate that both Fc gamma R and CR independently become associated with sIg when either receptor is loaded and sIg is cross-linked. | en |
| heal.journalName | Journal of Immunology | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| thyphronitis-1990-Interactions between Murine Lymphocyte-B Surface-Membrane Molecules.pdf | 601.4 kB | Adobe PDF | View/Open Request a copy |
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