Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/7723
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dc.contributor.authorMarangos, P.en
dc.contributor.authorVerschuren, E. W.en
dc.contributor.authorChen, R.en
dc.contributor.authorJackson, P. K.en
dc.contributor.authorCarroll, J.en
dc.date.accessioned2015-11-24T16:33:51Z-
dc.date.available2015-11-24T16:33:51Z-
dc.identifier.issn0021-9525-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7723-
dc.rightsDefault Licence-
dc.subject3T3 Cellsen
dc.subjectAnimalsen
dc.subjectCell Cycle Proteins/*metabolismen
dc.subjectCyclin B/metabolismen
dc.subjectEmbryo, Mammalian/cytology/metabolismen
dc.subjectF-Box Proteins/*metabolismen
dc.subjectFemaleen
dc.subjectGene Expression Regulationen
dc.subjectHumansen
dc.subjectMeiosisen
dc.subject*Meiotic Prophase Ien
dc.subject*Metaphaseen
dc.subjectMiceen
dc.subjectMitotic Spindle Appaen
dc.titleProphase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1)en
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1083/jcb.200607070-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17190794-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.publicationDate2007-
heal.abstractMammalian oocytes are arrested in prophase of the first meiotic division. Progression into the first meiotic division is driven by an increase in the activity of maturation-promoting factor (MPF). In mouse oocytes, we find that early mitotic inhibitor 1 (Emi1), an inhibitor of the anaphase-promoting complex (APC) that is responsible for cyclin B destruction and inactivation of MPF, is present at prophase I and undergoes Skp1-Cul1-F-box/betaTrCP-mediated destruction immediately after germinal vesicle breakdown (GVBD). Exogenous Emi1 or the inhibition of Emi1 destruction in prophase-arrested oocytes leads to a stabilization of cyclin B1-GFP that is sufficient to trigger GVBD. In contrast, the depletion of Emi1 using morpholino oligonucleotides increases cyclin B1-GFP destruction, resulting in an attenuation of MPF activation and a delay of entry into the first meiotic division. Finally, we show that Emi1-dependent effects on meiosis I require the presence of Cdh1. These observations reveal a novel mechanism for the control of entry into the first meiotic division: an Emi1-dependent inhibition of APC(Cdh1).en
heal.journalNameJ Cell Biolen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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