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DC Field | Value | Language |
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dc.contributor.author | Dimitriadis, E. | en |
dc.contributor.author | Trangas, T. | en |
dc.contributor.author | Milatos, S. | en |
dc.contributor.author | Foukas, P. G. | en |
dc.contributor.author | Gioulbasanis, I. | en |
dc.contributor.author | Courtis, N. | en |
dc.contributor.author | Nielsen, F. C. | en |
dc.contributor.author | Pandis, N. | en |
dc.contributor.author | Dafni, U. | en |
dc.contributor.author | Bardi, G. | en |
dc.contributor.author | Ioannidis, P. | en |
dc.date.accessioned | 2015-11-24T16:33:48Z | - |
dc.date.available | 2015-11-24T16:33:48Z | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/7714 | - |
dc.rights | Default Licence | - |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Colonic Neoplasms/*metabolism | en |
dc.subject | Female | en |
dc.subject | Gene Expression | en |
dc.subject | Humans | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Intestinal Mucosa/metabolism | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Prognosis | en |
dc.subject | RNA, Messenger/metabolism | en |
dc.subject | RNA-Binding Proteins/*metabolism | en |
dc.subject | Reverse Transc | en |
dc.title | Expression of oncofetal RNA-binding protein CRD-BP/IMP1 predicts clinical outcome in colon cancer | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.primary | 10.1002/ijc.22716 | - |
heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/17415713 | - |
heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/ijc.22716/asset/22716_ftp.pdf?v=1&t=h2a39dtf&s=4e5cfbc0e464f8835c0d1e17d5c0ada5d1ebfebd | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
heal.publicationDate | 2007 | - |
heal.abstract | The oncofetal CRD-BP/IMP1 RNA binding protein regulates posttranscriptionally a handful of RNA transcripts, implicated in cell adhesion and invadopodia formation and was recently identified as a target of the beta-catenin/Tcf transcription factor that is constitutively activated in colorectal carcinomas (CRCs). The expression of CRD-BP/IMP1 was studied in normal adult intestines and CRCs. In normal mucosa, CRD-BP/IMP1 immunoreactivity was observed in few scattered cells located predominantly at or near the bottom of the crypts, whereas in CRCs the protein was detectable in tumor cells of 50% of the specimens analyzed. CRD-BP/IMP1 mRNA expression was measured by qRT-PCR in 78 CRCs. Thirty-two (41%) of the specimens were negative or had negligible expression, whereas the remaining forty-six (59%) expressed a wide range of CRD-BP/IMP1 mRNA levels. CRD-BP/IMP1 mRNA expression correlated with that of the putative stem/progenitor cell marker Musashi-1 mRNA (p = 0. 035). CRD-BP/IMP1 positive tumors metastasized and/or recurred more frequently (p = 0.001) and its expression defined a group of patients with shorter survival (p = 0.014). Furthermore, in a multivariate analysis CRD-BP/IMP1 expression was found to be an independent predictor of survival (p = 0.015). For stage I & II patients, the differences in metastasis/recurrence and survival rates remained significant (p = 0.001 and 0.033, respectively). These findings indicate that CRD-BP/IMP1 positive tumors exhibit early disease dissemination and unfavorable prognosis. | en |
heal.journalName | Int J Cancer | en |
heal.journalType | peer reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) |
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Dimitriadis-2007-Expression of oncofe.pdf | 358.81 kB | Adobe PDF | View/Open Request a copy |
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