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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/7683
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dc.contributor.authorPotier, S.en
dc.contributor.authorSenecal, J.en
dc.contributor.authorChabot, J. G.en
dc.contributor.authorPsarropoulou, C.en
dc.contributor.authorDescarries, L.en
dc.date.accessioned2015-11-24T16:33:36Z-
dc.date.available2015-11-24T16:33:36Z-
dc.identifier.issn0953-816X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7683-
dc.rightsDefault Licence-
dc.subjectbindingen
dc.subjectepileptogenesisen
dc.subjectg-protein couplingen
dc.subjectmrnaen
dc.subjectmuscarinic receptorsen
dc.subjectguinea-pig brainen
dc.subjectbinding-sitesen
dc.subjectmessenger-rnaen
dc.subjectacetylcholine-receptorsen
dc.subjectneonatal seizuresen
dc.subjectregional expressionen
dc.subjectestrogen-treatmenten
dc.subjectcerebral-cortexen
dc.subjectsex-differencesen
dc.subjectnervous-systen
dc.titleA pentylenetetrazole-induced generalized seizure in early life enhances the efficacy of muscarinic receptor coupling to G-protein in hippocampus and neocortex of adult raten
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1111/j.1460-9568.2005.04026.x-
heal.identifier.secondary<Go to ISI>://000228751800007-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1460-9568.2005.04026.x/asset/j.1460-9568.2005.04026.x.pdf?v=1&t=hfxnu12o&s=319c3c5085b7d99b7b0e9f4f9ac8adbf42d595bb-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.publicationDate2005-
heal.abstractWe have previously shown that exposure to the anti-cholinesterase eserine provokes interictal-like discharges in the CA3 area of hippocampal slices from adult rats in which a generalized seizure has been induced by pentylenetetrazole (PTZ) when immature (at 20 days). Such increased responsiveness to acetylcholine (ACh) was not associated with any change in hippocampal acetylcholine or gamma-aminobutyric acid (GABA) content, GABAergic inhibition or density of ACh innervation, but was blocked by the muscarinic receptor antagonist atropine. We therefore turned to quantitative radioligand binding autoradiography, in situ hybridization and the [S-35]GTP gamma S method to assess the properties of hippocampal and neocortical muscarinic receptors in adult rats having experienced a PTZ seizure at P20. The densities of M1 and M2 receptor binding sites, respectively labeled with [H-3]pirenzepine and [H-3]AFDX-384, as well as the amount of m1, m2 and m3 receptor mRNAs, did not differ from control in the hippocampus and neocortex of these rats. In contrast, in PTZ rats, both brain regions displayed a marked increase in [S-35]GTP gamma S incorporation stimulated by ACh, bethanechol and particularly oxotremorine. This finding indicates that a generalized seizure in immature rat can entail a long-term and presumably permanent increase in the efficacy of G-protein coupling to muscarinic receptors in the hippocampus and neocortex of the adult. By analogy, such a mechanism could account for the susceptibility to epilepsy of human adults having suffered from prolonged convulsions in early life.en
heal.journalNameEuropean Journal of Neuroscienceen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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