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dc.contributor.authorIoannidis, P.en
dc.contributor.authorKottaridi, C.en
dc.contributor.authorDimitriadis, E.en
dc.contributor.authorCourtis, N.en
dc.contributor.authorMahaira, L.en
dc.contributor.authorTalieri, M.en
dc.contributor.authorGiannopoulos, A.en
dc.contributor.authorIliadis, K.en
dc.contributor.authorPapaioannou, D.en
dc.contributor.authorNasioulas, G.en
dc.contributor.authorTrangas, T.en
dc.rightsDefault Licence-
dc.subjectBrain Neoplasms/genetics/*metabolismen
dc.subjectCarcinoma, Large Cell/genetics/metabolismen
dc.subjectCarcinoma, Non-Small-Cell Lung/genetics/*metabolismen
dc.subjectCarcinoma, Squamous Cell/genetics/metabolismen
dc.subjectCase-Control Studieen
dc.titleExpression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumorsen
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.abstractThe coding region determinant-binding protein (CRD-BP) is an RNA binding protein that recognizes c-myc and IGF-II leader 3 mRNAs as well as the oncofetal H19 RNA. CRD-BP exhibits an oncofetal pattern of expression and has been detected in the majority of colon (81%), breast (58.5%) and sarcoma (73%) tumors. The study of CRD-BP expression was extended in brain tumors and Non small cell lung (NSCL) carcinomas and 12/24 malignant, 2/5 benign neuroepithelial tumors and 4/15 of NSCL carcinomas were found positive. All normal matching tissues tested were found negative. The highest frequency (60%) of CRD-BP positive tumors was observed in meningiomas, either benign (11/18) or atypical (3/3). These findings confirm that CRD-BP expression is restricted in tumors; the frequency of its de novo expression may vary according to tumor type and appears to be an early event in the transformation process.en
heal.journalNameCancer Letten
heal.journalTypepeer reviewed-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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