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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Comoy, E. E. | en |
| dc.contributor.author | Pestel, J. | en |
| dc.contributor.author | Duez, C. | en |
| dc.contributor.author | Stewart, G. A. | en |
| dc.contributor.author | Vendeville, C. | en |
| dc.contributor.author | Fournier, C. | en |
| dc.contributor.author | Finkelman, F. | en |
| dc.contributor.author | Capron, A. | en |
| dc.contributor.author | Thyphronitis, G. | en |
| dc.date.accessioned | 2015-11-24T16:31:54Z | - |
| dc.date.available | 2015-11-24T16:31:54Z | - |
| dc.identifier.issn | 0022-1767 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/7494 | - |
| dc.rights | Default Licence | - |
| dc.subject | cytokine gene-expression | en |
| dc.subject | low-affinity receptor | en |
| dc.subject | stimulatory factor-i | en |
| dc.subject | cd4+ lymphocytes-t | en |
| dc.subject | der-p-i | en |
| dc.subject | b-cell | en |
| dc.subject | schistosoma-mansoni | en |
| dc.subject | human ige | en |
| dc.subject | antibody-response | en |
| dc.subject | interferon-gamma | en |
| dc.title | The house dust mite allergen, Dermatophagoides pteronyssinus, promotes type 2 responses by modulating the balance between IL-4 and IFN-gamma | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | <Go to ISI>://000072115700054 | - |
| heal.identifier.secondary | http://www.jimmunol.org/content/160/5/2456.full.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
| heal.publicationDate | 1998 | - |
| heal.abstract | A common property of allergens is their potential to generate type 2 cytokine responses, To understand the mechanisms involved in this phenomenon, we have evaluated the polarizing potential of a major allergen, Dermatophagoides pteronyssinus 1 (Der p 1), in an heterologous immunization system using the glutathione S-transferase of the parasite Schistosoma mansoni (Sm28-GST) as immunogen. In previous studies, we showed that immunization with the Sm28-GST emulsified in CFA induced a nonpolarized immune response, In contrast, when alum was used as adjuvant, a type 2 immune response was induced against Sm28-GST, Using this experimental model, we examined whether the administration of Der p 1 together with Sm28-GST influenced the nonpolarized and/or the Th2 profiles induced by the CFA or the alum immunization, respectively, Our results showed that the introduction of Der p 1 in the CFA immunization protocol was associated with diminished anti-Sm28-GST IgG2a Ab titers, reduced IFN-gamma mRNA expression, and frequency of IFN-gamma-producing cells. In contrast, the introduction of Der p 1 in the alum protocol did not affect IL-4 or Ig isotype responses, The effect of Der p 1 was specific, since coimmunization with tetanus toxin fragment C did not affect the profile of the response against Sm28-GST, Furthermore, inactivation of Der p 1 reduced its ability to modify the immune response profile, suggesting that its protease activity played an important role in deviating the immune response. Our results suggest that the Der p 1 has the ability to modify the profile of an immune response by modulating the balance between the polarizing cytokines IL-4 and IFN-gamma. | en |
| heal.journalName | Journal of Immunology | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Comoy-1998-The house dust mite.pdf | 458.72 kB | Adobe PDF | View/Open Request a copy |
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