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https://olympias.lib.uoi.gr/jspui/handle/123456789/7485Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Schmidt, C. | en |
| dc.contributor.author | Ohlemeyer, C. | en |
| dc.contributor.author | Labrakakis, C. | en |
| dc.contributor.author | Walter, T. | en |
| dc.contributor.author | Kettenmann, H. | en |
| dc.contributor.author | Schnitzer, J. | en |
| dc.date.accessioned | 2015-11-24T16:31:49Z | - |
| dc.date.available | 2015-11-24T16:31:49Z | - |
| dc.identifier.issn | 0894-1491 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/7485 | - |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Animals, Newborn | en |
| dc.subject | Brain/*cytology | en |
| dc.subject | Cell Movement/*physiology | en |
| dc.subject | Cells, Cultured | en |
| dc.subject | Cerebellum/cytology | en |
| dc.subject | Electrophysiology | en |
| dc.subject | Immunohistochemistry | en |
| dc.subject | Laminin/pharmacology | en |
| dc.subject | Membrane Potentials | en |
| dc.subject | Oligodendroglia/*physiology | en |
| dc.subject | Patch-Clamp Techniques | en |
| dc.subject | Rats | en |
| dc.subject | R | en |
| dc.title | Analysis of motile oligodendrocyte precursor cells in vitro and in brain slices | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/9262233 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/(SICI)1098-1136(199708)20:4<284::AID-GLIA2>3.0.CO;2-6/asset/2_ftp.pdf?v=1&t=hh1pvw2j&s=bf0629fde1a08611b8cdc88a24f711568128b287 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
| heal.publicationDate | 1997 | - |
| heal.abstract | Oligodendrocyte precursor cells are purported to migrate over long distances into the various brain regions where they differentiate into oligodendrocytes and fulfill their appropriate tasks, i.e., myelination of axons. Here we characterize motile oligodendrocyte precursor cells in detail. Video-time lapse analysis was performed on isolated precursor cells in single cell cultures, in co-culture with cerebellar microexplants, and in living brain slices. Motility analysis of individual cells was combined with electrophysiological, immunological, and morphological characterizations. Translocation of the cell bodies was not continuous but occurred in waves. All motile cells exhibited a simple morphology and most, but not all, of them expressed the A2B5 epitope in vitro. Patch clamp analysis of the motile cells confirmed that they belong to the O-2A lineage. The percentage of motile cells, as well as their velocities, were enhanced on substrate-coated laminin in comparison to poly-L-lysine. Motility was not influenced by the presence of cerebellar microexplants. O-2A progenitor cells did not migrate strictly along neurite fascicles which were projected from the microexplants. Glial progenitor cells in situ also did not strictly migrate along the main direction of the axonal fibers of the corpus callosum but rather traversed the fibers with an overall direction toward the cortex. After Lucifer Yellow filling of the motile progenitor cells in situ, we could demonstrate that they were dye-coupled to yet unidentified cells of the corpus callosum. | en |
| heal.journalName | Glia | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Schmidt-1997-Analysis of motile o.pdf | 477.95 kB | Adobe PDF | View/Open Request a copy |
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