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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ρούτσιας, Ιωάννης Γ. | el |
| dc.date.accessioned | 2015-10-12T12:23:39Z | - |
| dc.date.available | 2015-10-12T12:23:39Z | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/403 | - |
| dc.identifier.uri | http://dx.doi.org/10.26268/heal.uoi.28 | - |
| dc.rights | Default License | - |
| dc.subject | Αντιγονική χαρτογράφηση | el |
| dc.subject | Αυτοαντισώματα | el |
| dc.subject | Επίτοποι | el |
| dc.subject | Καλρετικουλίνη | el |
| dc.subject | Σύνδρομο Sjogren | el |
| dc.subject | Συνθετικά πεπτίδια | el |
| dc.subject | Συστηματικός ερυθηματώδης λύκος ( ΣΕΛ) | el |
| dc.title | Καθορισμός αντιγονικών επιτόπων με σύνθεση πεπτιδικών αναλόγων για τη μελέτη της αυτοάνοσης απόκρισης στα αυτοάνοσα νοσήματα | el |
| heal.type | doctoralThesis | - |
| heal.type.en | Doctoral thesis | en |
| heal.type.el | Διδακτορική διατριβή | el |
| heal.classification | Ερυθηματώδης λύκος | el |
| heal.classification | Πεπτίδια | el |
| heal.classification | Συστηματικός | - |
| heal.identifier.secondary | http://thesis.ekt.gr/thesisBookReader/id/11190#page/1/mode/2u | - |
| heal.language | el | - |
| heal.access | free | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων Σχολή Ιατρικής Τμήμα Ιατρικής Τομέας Παθολογικός Κλινική Νεφρολογική Πανεπιστημιακού Γενικού Νοσοκομείου Ιωαννίνων | el |
| heal.publicationDate | 1998 | - |
| heal.bibliographicCitation | Βιβλιογραφία: σ. 275-278 | el |
| heal.abstract | AUTOIMMUNE RHEUMATIC DISEASES ARE OFTEN ASSOCIATED WITH AUTO ANTIBODIES AGAINST RIBONUCLEOPROTEIN COMPLEX RO/RNP. IN ORDER TO EXAMINE THE EXACT LOCATION OF THEIR EPITOPES, WE SYNTHESITED PEPTIDE ANALOGUES CORRESPONDING TO THE AMINO TERMINAL EPITOPE OF CALRETICULIN, TO VSV HOMOLOGOUS REGION OF RO 60KD PROTEIN AND USING LARGE OVERLAPPING SYNTHETIC PEPTIDES, AN EXTENSIVE EPITOPE MAPPING OF THE RO 60KD AUTOANTIGEN WAS PERFORMED. THE SYNTHETIC PEPTIDES OF CALRETICULIN REACTED WITH SERA FROM PATIENTS WITH SLE, SS, RA AND MCTD SUGGESTING THAT THEY ARE EPITOPES WITHOUT ANY DISEASE SPECIFICITY. THE EYRKKMDI VSVVIRUS RELATED PEPTIDE OF RO 60KD AUTOANTIGEN REACTED ONLY WITH A MINORITY OF ANTI-RO/SSA 60KD AUTOANTIBODIES, WHILE THE EPITOPE MAPPING OF THIS AUTOANTIGENREVEALED TWO MAIN DESEASE SPECIFIC EPITOPES LOCATED IN SEQUENCES 175-184 AND 216-232 OF RO/60KD. THE EPITOPE 175-184 POSSESSED SEQUENCE SIMILARITY WITHTHE ASSOCIATED WITH THE ANTI-RO /SSA RESPONCE HLA DR3 AND DRW3. SYNTHETIC HOMOLOGOUES PEPTIDES OF B-CHAIN OF HLA-DR WERE PREPAPED. THESE PEPTIDES WERE FOUND TO POSSESS COMMON MOLECULAR, STRUCTURAL AND IMMUNOLOGICAL PROPERTIES WITH THE EPITOPES OF RO /60KD, SUGGESTING CROSS-REACTION OF THE AUTOANTIBODIES. | en |
| heal.advisorName | 0 | - |
| heal.committeeMemberName | Μουτσόπουλος, Χαράλαμπος | el |
| heal.committeeMemberName | Σακαρέλλος, Κωνσταντίνος | el |
| heal.committeeMemberName | Σακαρέλλου-ΔαΪτσιώτου, Μαρία | el |
| heal.committeeMemberName | Σιαμόπουλος, Κωνσταντίνος | el |
| heal.committeeMemberName | Τσόλας, Ορέστης | el |
| heal.committeeMemberName | Δρόσος, Αλέξανδρος | el |
| heal.committeeMemberName | Τζιούφας, Αθανάσιος | el |
| heal.academicPublisher | Πανεπιστήμιο Ιωαννίνων Σχολή Ιατρικής Τμήμα Ιατρικής Τομέας Παθολογικός Κλινική Νεφρολογική Πανεπιστημιακού Γενικού Νοσοκομείου Ιωαννίνων | el |
| heal.academicPublisherID | uoi | - |
| heal.numberOfPages | 291 σ. | - |
| heal.fullTextAvailability | false | - |
| Appears in Collections: | Διδακτορικές Διατριβές - ΦΛΛ | |
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