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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/24758
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dc.contributor.authorPapadopoulou, C.en
dc.contributor.authorGeronikaki, A.en
dc.contributor.authorHadjipavlou-Litina, D.en
dc.date.accessioned2015-11-24T19:43:26Z-
dc.date.available2015-11-24T19:43:26Z-
dc.identifier.issn0014-827X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24758-
dc.rightsDefault Licence-
dc.subjectAmides/chemical synthesis/*pharmacologyen
dc.subjectAnimalsen
dc.subjectAnti-Inflammatory Agents/chemical synthesis/*pharmacologyen
dc.subjectBenzothiazoles/chemical synthesis/*pharmacologyen
dc.subjectCarrageenanen
dc.subjectDisease Models, Animalen
dc.subjectEdema/chemically induced/*prevention & controlen
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectMiceen
dc.subjectMice, Inbred AKRen
dc.subjectMolecular Structureen
dc.subjectPiperazines/*chemistryen
dc.subjectQuantitative Structure-Activity Relationshipen
dc.subjectRegression Analysisen
dc.subjectThiazoles/chemical synthesis/*pharmacologyen
dc.titleSynthesis and biological evaluation of new thiazolyl/benzothiazolyl-amides, derivatives of 4-phenyl-piperazineen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/j.farmac.2005.06.014-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16040029-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0014827X05001473/1-s2.0-S0014827X05001473-main.pdf?_tid=b71adac4a5799c80714aa8169091e7f2&acdnat=1332846832_d33e70bf8558a3828821fde4e8af6369-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2005-
heal.abstractA series of thiazolyl-N-phenyl piperazines has been synthesised and tested for anti-inflammatory activity. Their R(M) values were determined as an expression of their lipophilicity. Theoretical calculation of their lipophilicity, as clog P and logPsk also performed. The effect of the synthesised compounds on inflammation, using the carrageenin induced mouse paw oedema model was studied. In general, the studied compounds were found to be potent anti-inflammatory agents (44-74.1%). Anti-inflammatory activity was influenced by some structural characteristics of the synthesised compounds. An attempt was made to correlate their biological activity with some physicochemical parameters using a quantitative structure-activity relationship approach (QSAR).en
heal.journalNameFarmacoen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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