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  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/24726
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dc.contributor.authorKarageorgaki, Z. T.en
dc.contributor.authorBertsias, G. K.en
dc.contributor.authorMavragani, C. P.en
dc.contributor.authorKritikos, H. D.en
dc.contributor.authorSpyropoulou-Vlachou, M.en
dc.contributor.authorDrosos, A. A.en
dc.contributor.authorBoumpas, D. T.en
dc.contributor.authorMoutsopoulos, H. M.en
dc.date.accessioned2015-11-24T19:43:08Z-
dc.date.available2015-11-24T19:43:08Z-
dc.identifier.issn0392-856X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24726-
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAge of Onseten
dc.subjectAngiographyen
dc.subjectBlood Vessels/pathologyen
dc.subjectComorbidityen
dc.subjectDrug Therapy, Combinationen
dc.subjectFemaleen
dc.subjectGenes, MHC Class I/*immunologyen
dc.subjectGlucocorticoids/therapeutic useen
dc.subjectGreece/epidemiologyen
dc.subjectHLA-B Antigens/genetics/immunologyen
dc.subjectHumansen
dc.subject*Immunogenetic Phenomenaen
dc.subjectImmunosuppressive Agents/therapeutic useen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectRemission Inductionen
dc.subjectRetrospective Studiesen
dc.subject*Seroepidemiologic Studiesen
dc.subject*Takayasu Arteritis/epidemiology/genetics/immunology/therapyen
dc.subjectYoung Adulten
dc.titleTakayasu arteritis: epidemiological, clinical, and immunogenetic features in Greeceen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19646344-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2009-
heal.abstractOBJECTIVE: Takayasu arteritis (TA) is an uncommon disease with clinical heterogeneity across different ethnic groups. We aimed to evaluate the epidemiological, clinical, and immuno-genetic features of TA in Greece. METHODS: Demographic, clinical, laboratory, angiographic, and therapeutic data of 42 patients from 4 large referral centers were retrieved. Serology and Human Lymphocyte Antigen (HLA) typing was performed in 22 patients. RESULTS: We studied 37 women and 5 men with a median age of 31 years at disease onset. Median delay in diagnosis was 24 months and median follow-up was 47 months (range 0-178). Constitutional or musculoskeletal symptoms were present in 86%, especially early in the disease course. Vascular findings were universal with reduced or absent pulse being the most common manifestation (98%). Hypertension was frequent (78%). Extensive disease prevailed and stenotic lesions were more common than aneurysms (95% vs. 40%). Erythrocyte sedimentation rate and C-reactive protein showed modest correlation with disease activity. HLA-B52 was expressed by 37% of the patients vs. 2.4% of the controls (p<0.001). Glucocorticoids and cytotoxic agents were used in most patients with remission rates of 83%. A total of 42 surgical procedures were performed with success rates of 87%. CONCLUSION: TA in Greece clinically and epidemiologically resembles the pattern of disease in Japan and the Western hemisphere. There is considerable delay in diagnosis, which may partially reflect failure to recognize a rare disease. New surrogate markers are needed to assess disease activity. Glucocorticoids are the cornerstone of treatment and cytotoxic drugs are frequently used as steroid sparing agents.en
heal.journalNameClin Exp Rheumatolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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