1. Repository of OAI
  2. ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"
  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
Ελληνικά   English  
Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/24647
Full metadata record
DC FieldValueLanguage
dc.contributor.authorUitterlinden, A. G.en
dc.contributor.authorRalston, S. H.en
dc.contributor.authorBrandi, M. L.en
dc.contributor.authorCarey, A. H.en
dc.contributor.authorGrinberg, D.en
dc.contributor.authorLangdahl, B. L.en
dc.contributor.authorLips, P.en
dc.contributor.authorLorenc, R.en
dc.contributor.authorObermayer-Pietsch, B.en
dc.contributor.authorReeve, J.en
dc.contributor.authorReid, D. M.en
dc.contributor.authorAmedei, A.en
dc.contributor.authorBassiti, A.en
dc.contributor.authorBustamante, M.en
dc.contributor.authorHusted, L. B.en
dc.contributor.authorDiez-Perez, A.en
dc.contributor.authorDobnig, H.en
dc.contributor.authorDunning, A. M.en
dc.contributor.authorEnjuanes, A.en
dc.contributor.authorFahrleitner-Pammer, A.en
dc.contributor.authorFang, Y.en
dc.contributor.authorKarczmarewicz, E.en
dc.contributor.authorKruk, M.en
dc.contributor.authorvan Leeuwen, J. P.en
dc.contributor.authorMavilia, C.en
dc.contributor.authorvan Meurs, J. B.en
dc.contributor.authorMangion, J.en
dc.contributor.authorMcGuigan, F. E.en
dc.contributor.authorPols, H. A.en
dc.contributor.authorRenner, W.en
dc.contributor.authorRivadeneira, F.en
dc.contributor.authorvan Schoor, N. M.en
dc.contributor.authorScollen, S.en
dc.contributor.authorSherlock, R. E.en
dc.contributor.authorIoannidis, J. P.en
dc.date.accessioned2015-11-24T19:42:28Z-
dc.date.available2015-11-24T19:42:28Z-
dc.identifier.issn1539-3704-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24647-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBone Density/*geneticsen
dc.subjectDeoxyribonucleases, Type II Site-Specificen
dc.subjectFemaleen
dc.subjectFractures, Bone/geneticsen
dc.subjectGenotypeen
dc.subjectHaplotypesen
dc.subjectHomeodomain Proteins/*geneticsen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectOsteoporosis/*geneticsen
dc.subject*Polymorphism, Geneticen
dc.subjectPromoter Regions, Geneticen
dc.subjectProspective Studiesen
dc.subjectReceptors, Calcitriol/*geneticsen
dc.titleThe association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysisen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16908916-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2006-
heal.abstractBACKGROUND: Polymorphisms of the vitamin D receptor (VDR) gene have been implicated in the genetic regulation of bone mineral density (BMD). However, the clinical impact of these variants remains unclear. OBJECTIVE: To evaluate the relation between VDR polymorphisms, BMD, and fractures. DESIGN: Prospective multicenter large-scale association study. SETTING: The Genetic Markers for Osteoporosis consortium, involving 9 European research teams. PARTICIPANTS: 26,242 participants (18,405 women). MEASUREMENTS: Cdx2 promoter, FokI, BsmI, ApaI, and TaqI polymorphisms; BMD at the femoral neck and the lumbar spine by dual x-ray absorptiometry; and fractures. RESULTS: Comparisons of BMD at the lumbar spine and femoral neck showed nonsignificant differences less than 0.011 g/cm2 for any genotype with or without adjustments. A total of 6067 participants reported a history of fracture, and 2088 had vertebral fractures. For all VDR alleles, odds ratios for fractures were very close to 1.00 (range, 0.98 to 1.02) and collectively the 95% CIs ranged from 0.94 (lowest) to 1.07 (highest). For vertebral fractures, we observed a 9% (95% CI, 0% to 18%; P = 0.039) risk reduction for the Cdx2 A-allele (13% risk reduction in a dominant model). LIMITATIONS: The authors analyzed only selected VDR polymorphisms. Heterogeneity was detected in some analyses and may reflect some differences in collection of fracture data across cohorts. Not all fractures were related to osteoporosis. CONCLUSIONS: The FokI, BsmI, ApaI, and TaqI VDR polymorphisms are not associated with BMD or with fractures, but the Cdx2 polymorphism may be associated with risk for vertebral fractures.en
heal.journalNameAnn Intern Meden
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

Show simple item record
Files in This Item:
There are no files associated with this item.
Show simple item record  


This item is licensed under a Creative Commons License Creative Commons