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  2. ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"
  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/24645
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dc.contributor.authorLazaros, L.en
dc.contributor.authorXita, N.en
dc.contributor.authorKaponis, A.en
dc.contributor.authorHatzi, E.en
dc.contributor.authorPlachouras, N.en
dc.contributor.authorSofikitis, N.en
dc.contributor.authorZikopoulos, K.en
dc.contributor.authorGeorgiou, I.en
dc.date.accessioned2015-11-24T19:42:27Z-
dc.date.available2015-11-24T19:42:27Z-
dc.identifier.issn1745-7262-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24645-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAllelesen
dc.subjectAromatase/*geneticsen
dc.subjectBase Sequenceen
dc.subjectCase-Control Studiesen
dc.subjectDNA Primers/geneticsen
dc.subjectGene Frequencyen
dc.subject*Genetic Variationen
dc.subjectGenome-Wide Association Studyen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMicrosatellite Repeatsen
dc.subjectOligospermia/*enzymology/*genetics/pathologyen
dc.subject*Sperm Counten
dc.subjectSperm Motility/*genetics/*physiologyen
dc.subjectSpermatogenesis/genetics/physiologyen
dc.titleThe association of aromatase (CYP19) gene variants with sperm concentration and motilityen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1038/aja.2010.144-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21217768-
heal.identifier.secondaryhttp://www.nature.com/aja/journal/v13/n2/pdf/aja2010144a.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2011-
heal.abstractThe irreversible transformation of androgens into oestrogens is catalysed by cytochrome P450 aromatase. In the present study, we explored the contribution of the (TTTA)(n) polymorphism in the aromatase gene (CYP19) to sperm concentration and motility. Ninety normozoospermic and 60 oligospermic men were examined during infertility examinations. DNA was extracted from spermatozoa, and the CYP19 (TTTA)(n) polymorphism was genotyped by PCR. Genotype analysis revealed six CYP19 (TTTA)(n) alleles with 7-12 repeats. The allelic distribution of the CYP19 (TTTA)(n) polymorphism differed between normozoospermic and oligospermic men (P<0.01). Oligospermic men less frequently had long CYP19 alleles than did normozoospermic men (25 and 37.8%, respectively; P<0.02). The higher frequency of short CYP19 alleles in oligospermic men compared to normozoospermic men (43.3 and 28.3%, respectively; P<0.01) was primarily due to the distribution of the CYP19 (TTTA)(7) allele. The CYP19 (TTTA)(7) allele was associated with lower sperm concentration in normozoospermic men (P<0.01) and in the total study population (P<0.01); it was also associated with lower sperm motility in normozoospermic men (P<0.05) and in the total study population (P<0.01). In conclusion, the CYP19 (TTTA)(7) allele probably impairs aromatase activity, which in turn alters aromatase and oestrogen levels in the testis, leading to decreased sperm concentration and motility. These findings support the significance of cytochrome P450 aromatase in human spermatogenesis and consequently in semen quality.en
heal.journalNameAsian J Androlen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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