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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/24578
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dc.contributor.authorChristidis, D. S.en
dc.contributor.authorLiberopoulos, E. N.en
dc.contributor.authorKakafika, A. I.en
dc.contributor.authorMiltiadous, G. A.en
dc.contributor.authorCariolou, M.en
dc.contributor.authorGanotakis, E. S.en
dc.contributor.authorMikhailidis, D. P.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T19:42:03Z-
dc.date.available2015-11-24T19:42:03Z-
dc.identifier.issn1074-2484-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24578-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAnalysis of Varianceen
dc.subjectApolipoprotein A-I/blood/drug effectsen
dc.subjectApolipoproteins B/blood/drug effectsen
dc.subjectApolipoproteins E/blood/*geneticsen
dc.subjectBiological Markers/blooden
dc.subjectCholesterol, HDL/blood/drug effectsen
dc.subjectCholesterol, LDL/blood/drug effectsen
dc.subjectFemaleen
dc.subjectFenofibrate/*therapeutic useen
dc.subjectGene Frequency/drug effectsen
dc.subjectGenotypeen
dc.subjectHeptanoic Acids/*therapeutic useen
dc.subjectHumansen
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic useen
dc.subjectHyperlipidemia, Familial Combined/blood/drug therapy/geneticsen
dc.subjectHyperlipoproteinemia Type II/blood/drug therapy/geneticsen
dc.subjectHypertriglyceridemia/blood/drug therapy/geneticsen
dc.subjectHypolipidemic Agents/*therapeutic useen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subject*Polymorphism, Geneticen
dc.subjectPyrroles/*therapeutic useen
dc.subjectTreatment Outcomeen
dc.subjectTriglycerides/blooden
dc.titleThe effect of apolipoprotein E polymorphism on the response to lipid-lowering treatment with atorvastatin or fenofibrateen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1177/1074248406293732-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17056835-
heal.identifier.secondaryhttp://cpt.sagepub.com/content/11/3/211.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2006-
heal.abstractAlthough the effect of apolipoprotein E gene polymorphism on the response to treatment with statins has been studied, the results are conflicting. Moreover, little is known about the possible effect of apolipoprotein E alleles on the response to treatment with fibrates. The purpose of this study was to evaluate the effect of apolipoprotein E polymorphism on lipid-lowering response to treatment with atorvastatin and fenofibrate in patients with different types of dyslipidemia. The study population included 136 patients with heterozygous familial hypercholesterolemia (type IIA dyslipidemia) treated with atorvastatin (20 mg/day) and 136 patients with either primary hypertriglyceridemia (type IV dyslipidemia) or mixed hyperlipidemia (type IIB dyslipidemia) treated with micronized fenofibrate (200 mg/day). Overall, no significant associations were detected between apolipoprotein E genotype and response to treatment with atorvastatin. In patients treated with fenofibrate, significant associations were noted between apolipoprotein E genotype and changes in apolipoprotein B, apolipoprotein E and triglyceride levels. Specifically, in apolipoprotein E2, apolipoprotein E3, and apolipoprotein E4 individuals, apolipoprotein B reductions were 22%, 17%, and 8%, respectively (P = .003); apolipoprotein E reductions were 45%, 20%, and 15%, respectively (P = .006); whereas triglyceride reductions reached 53%, 36%, and 33%, respectively (P = .033). In conclusion, apolipoprotein E genotype had no significant effect on the response to treatment with atorvastatin in patients with heterozygous familial hypercholesterolemia, but in patients with primary hypertriglyceridemia or mixed hyperlipidemia, there was a clear association between apolipoprotein E genotype and response to treatment with fenofibrate.en
heal.journalNameJ Cardiovasc Pharmacol Theren
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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