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https://olympias.lib.uoi.gr/jspui/handle/123456789/24573Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Tsangaris, I. | en |
| dc.contributor.author | Galiatsou, E. | en |
| dc.contributor.author | Kostanti, E. | en |
| dc.contributor.author | Nakos, G. | en |
| dc.date.accessioned | 2015-11-24T19:42:02Z | - |
| dc.date.available | 2015-11-24T19:42:02Z | - |
| dc.identifier.issn | 0342-4642 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24573 | - |
| dc.rights | Default Licence | - |
| dc.subject | Apache | en |
| dc.subject | Adult | en |
| dc.subject | Anoxia/*therapy | en |
| dc.subject | Humans | en |
| dc.subject | Injury Severity Score | en |
| dc.subject | Middle Aged | en |
| dc.subject | Pulmonary Gas Exchange | en |
| dc.subject | Respiration, Artificial | en |
| dc.subject | Respiratory Distress Syndrome, Adult/classification/*therapy | en |
| dc.subject | Surface-Active Agents/*therapeutic use | en |
| dc.title | The effect of exogenous surfactant in patients with lung contusions and acute lung injury | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1007/s00134-007-0597-z | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/17377767 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/xu02567106084315/fulltext.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2007 | - |
| heal.abstract | OBJECTIVE: To investigate the acute effect of surfactant replacement in multiple-trauma patients with lung contusion and acute lung injury. DESIGN AND SETTING: Prospective randomized clinical trial in the 14-bed ICU of a 750-bed university hospital. PATIENTS AND PARTICIPANTS: Sixteen ventilated trauma patients with severe refractory hypoxemia (PaO(2)/FIO(2)<150 mmHg) and lung contusions. INTERVENTIONS: Patients were randomly assigned to either surfactant administration (n=8) or standard treatment (n=8). A single dose of natural bovine surfactant was instilled bronchoscopically in the involved lung areas; each segmental bronchus received (200/19) mg/kg body weight. MEASUREMENTS AND RESULTS: The surfactant group demonstrated an acute improvement in oxygenation after surfactant replacement compared both to control group and to baseline values. In the surfactant group PaO(2)/FIO(2) increased from 100+/-20 mmHg at baseline to 140+/-20 (6 h), 163+/-26 (12 h), and 187+/-30 mmHg (24h). Compliance increased from 30 to 36 ml/cmH(2)O at 6 h after administration, and this increase remained significant at the 24, 48, and 72 h time points. The surfactant group demonstrated a higher response to recruitment maneuvers than the control group at 6 h. The mean duration of ventilatory support was 5.6 +/-2.6 days in the surfactant group and 8.1+/-2.4 days in the control group. CONCLUSIONS: Surfactant replacement was well tolerated in patients with lung contusions and severe hypoxemia and resulted in improved oxygenation and compliance. | en |
| heal.journalName | Intensive Care Med | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Tsangaris-2007-The effect of exogen.pdf | 125.33 kB | Adobe PDF | View/Open Request a copy |
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