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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/24553
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dc.contributor.authorFilippatos, T. D.en
dc.contributor.authorGazi, I. F.en
dc.contributor.authorLiberopoulos, E. N.en
dc.contributor.authorAthyros, V. G.en
dc.contributor.authorElisaf, M. S.en
dc.contributor.authorTselepis, A. D.en
dc.contributor.authorKiortsis, D. N.en
dc.date.accessioned2015-11-24T19:41:53Z-
dc.date.available2015-11-24T19:41:53Z-
dc.identifier.issn0021-9150-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24553-
dc.rightsDefault Licence-
dc.subject1-Alkyl-2-acetylglycerophosphocholine Esterase/*blooden
dc.subjectAdulten
dc.subjectAnti-Obesity Agents/pharmacology/therapeutic useen
dc.subjectCardiovascular Diseases/drug therapy/etiologyen
dc.subjectCholesterol, LDL/*blooden
dc.subjectDrug Therapy, Combinationen
dc.subjectFemaleen
dc.subjectFenofibrate/pharmacology/*therapeutic useen
dc.subjectHumansen
dc.subjectHypolipidemic Agents/pharmacology/therapeutic useen
dc.subjectLactones/pharmacology/*therapeutic useen
dc.subjectMaleen
dc.subjectMetabolic Syndrome X/drug therapy/etiologyen
dc.subjectMiddle Ageden
dc.subjectObesity/complications/*drug therapyen
dc.subjectOverweighten
dc.subjectPhospholipases A2en
dc.subjectRisk Factorsen
dc.titleThe effect of orlistat and fenofibrate, alone or in combination, on small dense LDL and lipoprotein-associated phospholipase A2 in obese patients with metabolic syndromeen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/j.atherosclerosis.2006.07.010-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16911813-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0021915006004084/1-s2.0-S0021915006004084-main.pdf?_tid=d29956a44a96251d298a203a6bbb2079&acdnat=1333531139_a7897d9d8d05921b4cdc9ffe783e74bc-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2007-
heal.abstractBACKGROUND: Increased concentration of small dense LDL cholesterol (sdLDL-C) and activity of lipoprotein-associated phospholipase A2 (Lp-PLA(2)) are considered as emerging cardiovascular risk factors and are commonly encountered in subjects with metabolic syndrome (MetS). OBJECTIVE: The primary endpoint of this study was the effect of orlistat and fenofibrate, alone or in combination, on Lp-PLA(2) activity and LDL phenotype in overweight and obese patients (body mass index>28 kg/m(2)) with MetS. METHODS: Patients (n=89) were prescribed a low-fat low-calorie diet and were randomly allocated to receive orlistat 120 mg three times daily (O group), micronized fenofibrate 200mg/day (F group) or both (OF group) for 6 months. RESULTS: Significant reductions of sdLDL-C levels were observed in all treatment groups. Groups F and OF experienced a greater reduction in sdLDL-C levels (p<0.05) together with a greater increase in LDL particle diameter (p<0.05) compared with group O. Total plasma Lp-PLA(2) activity significantly decreased in all treatment groups. The reduction of Lp-PLA(2) was more pronounced with OF administration compared with each monotherapy (p<0.05). CONCLUSION: Orlistat and fenofibrate exhibited favorable effects on Lp-PLA(2) activity and LDL phenotype in overweight and obese patients with MetS. Importantly, combination treatment had a more favorable effect on these risk factors.en
heal.journalNameAtherosclerosisen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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