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  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/24529
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dc.contributor.authorKalambokis, G.en
dc.contributor.authorEconomou, M.en
dc.contributor.authorFotopoulos, A.en
dc.contributor.authorAl Bokharhii, J.en
dc.contributor.authorPappas, C.en
dc.contributor.authorKatsaraki, A.en
dc.contributor.authorTsianos, E. V.en
dc.date.accessioned2015-11-24T19:41:46Z-
dc.date.available2015-11-24T19:41:46Z-
dc.identifier.issn0002-9270-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24529-
dc.rightsDefault Licence-
dc.subjectAdministration, Oralen
dc.subjectAdrenergic alpha-Agonists/*administration & dosageen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAldosterone/blooden
dc.subjectBlood Flow Velocity/drug effectsen
dc.subjectDrug Therapy, Combinationen
dc.subjectFemaleen
dc.subjectGlomerular Filtration Rate/drug effectsen
dc.subjectGlucagon/blooden
dc.subjectHemodynamics/*drug effectsen
dc.subjectHepatorenal Syndrome/*drug therapyen
dc.subjectHumansen
dc.subjectInjections, Subcutaneousen
dc.subjectKidney/*blood supplyen
dc.subject*Kidney Function Testsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMidodrine/*administration & dosageen
dc.subjectOctreotide/*administration & dosageen
dc.subjectRegional Blood Flow/drug effectsen
dc.subjectRenin/blooden
dc.subjectVascular Resistance/drug effectsen
dc.titleThe effects of chronic treatment with octreotide versus octreotide plus midodrine on systemic hemodynamics and renal hemodynamics and function in nonazotemic cirrhotic patients with ascitesen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1111/j.1572-0241.2005.40899.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15784036-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2005-
heal.abstractOBJECTIVES: The adrenergic agonist midodrine improved circulatory and renal dysfunction when acutely administered in nonazotemic cirrhotic patients with ascites while its combination with octreotide has recently been proposed as an effective treatment of type 1 hepatorenal syndrome (HRS). However, the effects of octreotide on systemic hemodynamics and renal function in cirrhotic patients are controversial. This study evaluated the effects of chronic treatment with octreotide versus octreotide plus midodrine on systemic hemodynamics and renal hemodynamics, and function in nonazotemic cirrhotic patients with ascites. METHODS: Twenty-five patients were studied at baseline and 11 days after administration of subcutaneous octreotide 300 mug, b.i.d. alone (n = 12) or together with oral midodrine 7.5 mg, t.i.d. (n = 13). RESULTS: Octreotide did not improve systemic hemodynamics whereas the addition of midodrine significantly decreased cardiac index (CI) and heart rate (HR), and increased mean arterial pressure (MAP) and systemic vascular resistance (SVR). Octreotide caused a decrease in renal vascular resistance (RVR) and increased renal blood flow (RBF) but significantly reduced glomerular filtration rate. The association of midodrine to octreotide did not modify renal hemodynamics and function as compared to baseline while it caused an almost significant minor increase in RVR and a significant minor decrease in RBF as compared to octreotide alone. Consequently, a significant minor increase in glomerular filtration rate was demonstrated. The plasma values of active renin, aldosterone, and glucagon were significantly reduced in either group. CONCLUSIONS: Octreotide does not improve systemic hemodynamics in nonazotemic cirrhotic patients with ascites while it impairs renal function. On the other hand, the addition of midodrine can ameliorate the hyperdynamic circulation without inducing renal dysfunction in these patients.en
heal.journalNameAm J Gastroenterolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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