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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Tzoufi, M. | en |
| dc.contributor.author | Mentzelopoulos, S. D. | en |
| dc.contributor.author | Roussos, C. | en |
| dc.contributor.author | Armaganidis, A. | en |
| dc.date.accessioned | 2015-11-24T19:41:41Z | - |
| dc.date.available | 2015-11-24T19:41:41Z | - |
| dc.identifier.issn | 0003-2999 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24520 | - |
| dc.rights | Default Licence | - |
| dc.subject | Aerosols | en |
| dc.subject | Aged | en |
| dc.subject | Albuterol/administration & dosage/*pharmacology | en |
| dc.subject | Body Weight/physiology | en |
| dc.subject | Bronchodilator Agents/administration & dosage/*pharmacology | en |
| dc.subject | Electrocardiography | en |
| dc.subject | Female | en |
| dc.subject | Functional Residual Capacity | en |
| dc.subject | Hemodynamics/drug effects/*physiology | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | *Positive-Pressure Respiration | en |
| dc.subject | Pulmonary Disease, Chronic Obstructive/drug therapy/*physiopathology/*therapy | en |
| dc.subject | Pulmonary Gas Exchange/drug effects/*physiology | en |
| dc.subject | Respiratory Mechanics/drug effects/*physiology | en |
| dc.title | The effects of nebulized salbutamol, external positive end-expiratory pressure, and their combination on respiratory mechanics, hemodynamics, and gas exchange in mechanically ventilated chronic obstructive pulmonary disease patients | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1213/01.ane.0000167276.92462.ba | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/16116002 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2005 | - |
| heal.abstract | We hypothesized that combined salbutamol and external positive end-expiratory pressure (PEEPe) may present additive benefits in chronic obstructive pulmonary disease (COPD) exacerbation. In 10 anesthetized, mechanically ventilated, and bronchodilator-responsive COPD patients exhibiting moderate intrinsic PEEP (PEEPi), we assessed respiratory system (rs) mechanics, hemodynamics, and gas exchange at (a) baseline (zero PEEPe [ZEEPe]), (b) 30 min after 5 mg of nebulized salbutamol administration (ZEEPe-S), (c) 30 min after setting PEEPe at baseline PEEPi level (PEEPe), and (d) 30 min after 5 mg of nebulized salbutamol administration with PEEPe maintained unchanged (PEEPe-S). Return of determined variable values to baseline values was confirmed before PEEPe application. Relative to ZEEPe, (a) at ZEEP-S, PEEPi (4.8 +/- 0.7 versus 7.0 +/- 1.1 cm H(2)O), functional residual capacity change (115.6 +/- 23.1 versus 202.1 +/- 46.0 mL), minimal rs (airway) resistance (9.3 +/- 1.4 versus 11.8 +/- 2.2 cm H(2)O.L(-1).s(-1)), and additional rs resistance (5.2 +/- 1.4 versus 7.2 +/- 1.3 cm H(2)O.L(-1).s(-1)) were reduced (P < 0.01), and hemodynamics were improved; (b) at PEEPe, PEEPi (3.7 +/- 1.3 cm H(2)O) was reduced (P < 0.01), and gas exchange was improved; and (c) at PEEPe-S, PEEPi (2.0 +/- 1.2 cm H(2)O) was minimized, and rs mechanics (static rs elastance included), hemodynamics, and gas exchange were improved. Conclusively, in carefully preselected COPD patients, bronchodilation/PEEPe exhibits additive benefits. | en |
| heal.journalName | Anesth Analg | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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