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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/24515
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dc.contributor.authorKondomerkos, D. J.en
dc.contributor.authorKalamidas, S. A.en
dc.contributor.authorMichalis, L. K.en
dc.contributor.authorKanavaros, P.en
dc.date.accessioned2015-11-24T19:41:39Z-
dc.date.available2015-11-24T19:41:39Z-
dc.identifier.issn0258-851X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24515-
dc.rightsDefault Licence-
dc.subjectAcid Phosphatase/metabolismen
dc.subjectAnimalsen
dc.subjectCarrier Proteins/pharmacologyen
dc.subjectCaspase 9en
dc.subjectCaspases/pharmacologyen
dc.subjectCells, Cultureden
dc.subjectChromones/pharmacologyen
dc.subjectCyclic AMP/metabolismen
dc.subject*Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitorsen
dc.subjectDactinomycin/pharmacologyen
dc.subjectEnzyme Inhibitors/*pharmacologyen
dc.subjectFemaleen
dc.subjectIsoquinolines/pharmacologyen
dc.subjectLipoproteins, LDL/*pharmacologyen
dc.subjectMacrophage Activation/*drug effectsen
dc.subjectMacrophages, Peritoneal/*drug effects/metabolismen
dc.subjectMaleen
dc.subjectMorpholines/pharmacologyen
dc.subjectNitric Oxide/metabolismen
dc.subject*Phosphatidylinositol 3-Kinases/antagonists & inhibitorsen
dc.subjectRatsen
dc.subjectRats, Wistaren
dc.subjectSignal Transduction/drug effectsen
dc.subjectSpecific Pathogen-Free Organismsen
dc.subjectSulfonamides/pharmacologyen
dc.titleThe effects of phosphoinositide/calcium- or cyclic AMP-mediated signal transduction pathway inhibitors on the activation of rat peritoneal macrophages by acetylated low-density lipoproteinen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15523908-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2004-
heal.abstractBACKGROUND: Macrophages that uptake modified lipoproteins are activated and may initially behave as endotoxin-stimulated macrophages. This study was undertaken in order to determine whether signal transduction pathways controlling endotoxin-mediated activation may also influence the lipoprotein-mediated activation of macrophages. MATERIALS AND METHODS: Rat peritoneal macrophages were incubated for 16 hours with acetylated low-density lipoprotein and certain agents that modify the phosphoinositide/calcium- and cyclic AMP-mediated pathways, such as 2-[4-morpholinyl]-8-phenyl-1[4H]-benzopyran-4-one (LY-294002), autocamtide 2-related inhibitory peptide (AIP), N-(2-[p-bromocinnamylamino]-ethyl)-5-isoquinolinesulfonamide hydrochloride (H-89) and actinomycin D. The production of nitric oxide and the intracellular and extracellular activities of acid phosphatase were assayed. RESULTS: Macrophages incubated with acetylated low-density lipoprotein showed an increased production of nitric oxide and intracellular acid phosphatase activity as compared to their controls. LY-294002, AIP and H-89 caused a significant decrease in nitric oxide production and intracellular acid phosphatase activity. Actinomycin D had similar effects. AIP and actinomycin also significantly increased extracellular acid phosphatase activity. CONCLUSION: The activation of peritoneal macrophages by acetylated low-density lipoprotein was similar to the activation by endotoxin, as expressed by the nitric oxide production and acid phosphatase intracellular activity; agents controlling the phosphoinositide/calcium- and cyclic AMP-mediated pathways in endotoxin-activated macrophages also influence the acetylated low-density lipoprotein-activated macrophages.en
heal.journalNameIn Vivoen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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