Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/24497
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dc.contributor.authorFotsis, T.en
dc.contributor.authorZhang, Y.en
dc.contributor.authorPepper, M. S.en
dc.contributor.authorAdlercreutz, H.en
dc.contributor.authorMontesano, R.en
dc.contributor.authorNawroth, P. P.en
dc.contributor.authorSchweigerer, L.en
dc.date.accessioned2015-11-24T19:41:33Z-
dc.date.available2015-11-24T19:41:33Z-
dc.identifier.issn0028-0836-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24497-
dc.rightsDefault Licence-
dc.subject3T3 Cellsen
dc.subjectAdministration, Oralen
dc.subjectAnimalsen
dc.subjectAntineoplastic Agents/*pharmacologyen
dc.subjectCattleen
dc.subjectCells, Cultureden
dc.subjectDrug Screening Assays, Antitumoren
dc.subjectEndothelium, Vascular/cytology/drug effectsen
dc.subjectEstradiol/*analogs & derivatives/pharmacologyen
dc.subjectFibroblast Growth Factor 2/pharmacologyen
dc.subjectHumansen
dc.subjectMelanoma, Experimental/blood supply/drug therapyen
dc.subjectMiceen
dc.subjectNeovascularization, Pathologic/*prevention & controlen
dc.subjectSarcoma, Experimental/blood supply/drug therapyen
dc.subjectTumor Cells, Cultureden
dc.titleThe endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growthen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1038/368237a0-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7511798-
heal.identifier.secondaryhttp://www.nature.com/nature/journal/v368/n6468/abs/368237a0.html-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1994-
heal.abstractThe formation of new blood vessels (angiogenesis) is critical for the growth of tumours and is a dominant feature in various angiogenic diseases such as diabetic retinopathy, arthritis, haemangiomas and psoriasis. Recognition of the potential therapeutic benefits of controlling pathological angiogenesis has led to a search for angiogenesis inhibitors. Here we report that 2-methoxyoestradiol, an endogenous oestrogen metabolite of previously unknown function, is a potent inhibitor of endothelial cell proliferation and migration as well as angiogenesis in vitro. Moreover, when administered orally in mice, it strongly inhibits the neovascularization of solid tumors and suppresses their growth. Unlike the angiostatic steroids of corticoid structure, it does not require the co-administration of heparin or sulphated cyclodextrins for activity. Thus, 2-methoxyoestradiol is the first steroid to have high antiangiogenic activity by itself. Our results suggest that this compound may have therapeutic potential in cancer and other angiogenic diseases.en
heal.journalNameNatureen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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